20 articles
Somatic mutations found in cancer driver genes accumulate in Alzheimer's brain macrophages, potentially driving the neuroinflammation that accelerates disease.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
Scientists discover adult brain cells keep epigenetic memories from development that may fuel gliomas but also enhance regeneration.
New brain atlas reveals three distinct phases of blood vessel development that coordinate with neural circuit maturation in developing mice.
A landmark multi-omic atlas of 100 GBM patients uncovers four malignant cellular communities and new therapeutic targets.
A 6,000+ organoid study links specific cellular phenotypes to microcephaly, polymicrogyria, epilepsy, and intellectual disability with 92% classification accuracy.
Researchers discover autoimmune and acquired conditions can mimic Huntington's disease, affecting 2-40% of patients with similar symptoms.
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.
Scientists discover brain support cells help glioblastoma grow and identify existing HIV drug that could disrupt this deadly communication.
New research reveals the brain actively directs development of its surrounding lymphatic immune network via specialized glial cells and neural signals.
Scientists use brain organoids to capture individual differences in brain development, offering new insights into neurological health.
Autopsy study of 162 patients shows cerebral amyloid angiopathy affects all brain regions equally, not just bleeding sites.
New research reveals dendrite branching is driven by random growth, with ligand contacts acting as brakes to sculpt precise neural architecture.
New research reveals how brain immune cells respond to vascular damage, offering clues for early Alzheimer's intervention strategies.
New single-nucleus RNA sequencing reveals immature neurons persist in aged human hippocampus and may actively support cognitive resilience in Alzheimer's disease.
New spatiotemporal mapping of the human meninges exposes how immune cells and brain barriers co-develop from 6–23 gestational weeks.
New research reveals that the molecular state of immature neurons in the aged hippocampus predicts cognitive resilience — not just their number.
A multi-omics subspace-merging algorithm identifies biologically distinct AD subtypes, pointing toward personalized treatment strategies.
A landmark Nature Neuroscience study reveals how peripheral immune cells infiltrate the spinal cord in ALS, pointing to targeted immunotherapy.
Analysis of 177 cases with E200K mutation identifies new disease patterns that could improve diagnosis and understanding.
