20 articles
Researchers identify four LSC subtypes that predict venetoclax resistance and reveal matched subtype-specific therapies for AML patients.
A first-in-human trial shows CAR-modified stem cell memory T cells outperform standard CAR T cells in expansion, persistence, and complete responses.
New research reveals how a specific protein causes anemia in myelodysplastic syndromes and predicts treatment response.
New research reveals how lung cancer subclones develop distinct immune evasion strategies, complicating immunotherapy response.
New research reveals how B cell lymphomas disrupt immune system organization through chemokine manipulation.
A sweeping review of CAR-T and CAR-NK cell therapies in acute myeloid leukemia, covering clinical trial outcomes, key targets, and next-gen strategies.
Scientists identify a mitochondria-proteasome-haem pathway that silences immune cells — and show bortezomib can fix it in CAR-T therapy.
A 13-modality molecular analysis of 173 AML patients reveals distinct subtypes, metabolic reprogramming, and a machine-learning-validated therapy target.
A landmark WGS study of 1,804 myeloid neoplasia patients uncovers how telomere length varies by mutation type and cancer subtype.
BCG therapy for bladder cancer travels to bone marrow, reprogramming stem cells to produce enhanced immune cells that fight tumors throughout the body.
AML stem cells produce BHB via autonomous ketogenesis to block ferroptosis, revealing a targetable metabolic vulnerability in leukemia.
A landmark Cell study reveals that the patient's own immune system—not just CAR T cells—decides outcomes in recurrent glioblastoma.
Multi-omics study reveals exhausted T-cells in CLL lymph nodes and identifies galectin-9 as a promising therapeutic target for overcoming immune evasion.
New molecular analysis tool could revolutionize treatment decisions for chronic myelomonocytic leukemia patients.
A comprehensive review reveals how combining genomics, proteomics, and metabolomics is uncovering new AML targets and improving patient outcomes.
Researchers identify how HER2 expression patterns reveal functional changes in breast cancer cells circulating through blood.
Scientists discover how breast cancer builds deadly metastases using a 3D branching pattern, revealing new treatment targets.
MIT researchers identify oncofetal cell states in colorectal tumors that mimic embryonic intestines and prime cancer cells for invasion.
New study reveals how cancer cells reprogram bone immune cells to fuel metastasis, offering potential therapeutic targets.
Massive spatial analysis reveals conserved fibroblast subtypes that control immune infiltration and therapy response across cancer types.
