Cancer Cells Form Clusters to Boost Metastasis Through Metabolic Reprogramming
New research reveals how cancer cells cluster together to switch their metabolism and successfully colonize distant organs.
20 articles
New research reveals how cancer cells cluster together to switch their metabolism and successfully colonize distant organs.
Researchers found a dual-target approach that selectively destroys the most treatment-resistant form of acute myeloid leukemia.
New evidence reveals mitochondria form functionally distinct subpopulations within tissues and even single cells, reshaping how we understand energy metabolism.
New research reveals how blood vessel maturity around transplanted insulin-producing cells determines long-term survival.
An erratum to a 2022 Cell Metabolism paper describing a bone marrow lipolytic factor that links mechanical force to bone formation and lymphocyte production.
New research reveals how mitochondrial metabolism regulates dendritic cells' ability to activate anti-tumor immunity.
Researchers shift from systemic B-cell targeting to localized immune control, potentially improving transplant success rates.
Scientists identify how different immune cells use specific nutrient transporters, revealing new targets for autoimmune diseases.
Finnish study identifies distinct metabolic signatures for different genetic diabetes risk patterns, opening doors to personalized prevention.
Researchers explore targeted immune strategies to improve pancreatic islet transplant success rates for diabetes treatment.
New research reveals how RAP1A protein regulates liver blood vessel function and may influence fibrosis progression in chronic liver disease.
Machine learning clusters CGM data into four distinct glycemic patterns, each linked to unique diabetic complication risks.
Blocking mTOR forces cancer cells to rewire cholesterol uptake and transport, revealing new drug targets when combined with rapamycin.
Scientists discover how PDAP1 protein reprograms liver cells to burn less fat and make more, driving hepatocellular carcinoma progression.
New research reveals how specific gene combinations affect how quickly pre-diabetes advances to full type 1 diabetes.
New research identifies choline kinase alpha as a key driver of diabetic retinopathy and microvascular dysfunction.
New research reveals how glucose metabolism directly controls fat tissue expansion through a novel epigenetic pathway involving JMJD1A.
New cryo-EM structures reveal how LYCHOS protein senses cholesterol levels to regulate mTORC1 signaling, offering drug targets for aging.
Research reveals how the steroid hormone pregnenolone allows cancer cells to evade immune detection and reduces immunotherapy effectiveness.
A Japanese family case reveals how inherited HNF1A and ABCC8 mutations act additively to accelerate early-onset diabetes beyond either variant alone.