20 articles
New guidance on using clonal hematopoiesis markers and inherited syndrome testing to evaluate cytopenias and bone marrow failure.
Blood stem cell mutations may actually improve immune checkpoint therapy effectiveness against cancer tumors.
Splicing factor mutations rescue blood stem cells from telomere shortening, revealing a new mechanism linking aging, clonal hematopoiesis, and leukemia risk.
Large-scale proteomics uncovers distinct plasma protein patterns linked to DNMT3A, TET2, and other CH mutations, illuminating inflammatory pathways.
Scientists review how hematopoietic stem cells become senescent with age and identify promising therapeutic strategies to restore blood system function.
Scientists identify key molecular pathways that distinguish different types of anemia, opening doors to precision treatments.
Scientists generate true hematopoietic stem cells from human iPSCs that repopulate multiple blood lineages long-term, rivaling cord blood transplants.
A microbial sugar molecule leaking from an aging gut selectively expands pre-leukemic blood stem cells, revealing a new therapeutic target.
A landmark Nature study shows metformin can suppress the clonal advantage of DNMT3A-mutant blood stem cells, potentially preventing leukemia progression.
New research reveals how aging blood stem cells trigger inflammation and immune dysfunction that accelerates aging throughout the body.
Scientists reveal how MYC/BCL2 double-hit lymphomas evade BCR signaling and identify new therapeutic vulnerabilities in this deadly cancer.
A landmark multi-omic study maps the full metabolic landscape of human bone marrow stem cells, revealing choline as a key stemness regulator.
Radioresistant intrathymic stem cells and a secreted growth factor called THGF may hold the key to thymic recovery after irradiation and cancer risk.
AML is a fast-moving blood cancer with poor prognosis in aging populations. Here's what clinicians and patients need to know.
A 374-patient multiomics study maps AML's proteomic landscape, uncovers hematopoietic aging patterns, and builds a prognostic scoring tool.
Blood stem cells lacking DNMT3A gain telomerase activity and indefinite self-renewal — revealing a non-canonical longevity mechanism in clonal aging.
A megakaryocyte-secreted protein declines with age and drives hematopoietic stem cell aging — and restoring it rejuvenates aged blood stem cells.
New research reveals how heart muscle cells become polyploid during development, creating barriers to heart regeneration after injury.
A landmark single-cell atlas of 35 human tissues reveals 12 multicellular coordination modules—and shows how cancer systematically dismantles them.
Ossium Health is banking donor bone marrow for on-demand transplant, targeting immune aging as a future healthspan intervention.
