20 articles
A senolytic pairing of dasatinib and quercetin cleared senescent cells at the tendon-bone junction, dramatically improving repair strength in aged rats.
Scientists discover how tumors use glucose to survive lysosome-blocking drugs, revealing promising combination therapies.
A novel anti-swelling hydrogel loaded with dasatinib, quercetin, and nucleus pulposus exosomes clears senescent cells and restores disc integrity in rats and goats.
Explore the molecular mechanisms of cellular senescence and how p16/p21 pathways drive SASP production, plus cutting-edge senolytic drug targets.
Revolution Medicines' RAS inhibitor daraxonrasib shows breakthrough results in pancreatic cancer, doubling patient survival times.
ProcyanidinC1, a natural senolytic, selectively eliminates senescent cells in diabetic skin, dramatically improving wound healing in mouse models.
The FDA greenlights a new antibody-drug conjugate for aggressive breast cancer, expanding first-line treatment options for patients.
Discover how revolutionary drugs target 'zombie cells' that accumulate with age, potentially reversing aging and extending healthspan.
BioNTech reports positive Phase 2 results for HER2-targeted cancer therapy, with FDA filing planned to compete with existing treatments.
Scientists discover how plant compounds enhance stem cell therapy for kidney disease through improved cellular messaging.
A second wave of RAS-targeting therapies is reshaping cancer treatment, with implications for longevity through better tumor control.
Breakthrough review reveals how modern diabetes treatments protect multiple organs and may extend healthy lifespan through novel mechanisms.
New research identifies a drug target that could help millions of fractures heal properly when blood flow is compromised.
Blocking zinc transport in stem cell-derived pancreatic islets improves their survival and function after transplantation for diabetes treatment.
Researchers develop innovative method to guide immune cells to pancreatic tumors using engineered viruses and targeted cytokines.
New research shows GDF11 protein can prevent and treat steroid-induced bone death by activating blood vessel formation pathways.
MSC-derived exosomes delivered via ear injection protect vestibular hair cells, cut apoptosis, and boost autophagy better than dexamethasone.
Researchers found that inhibiting LSD1 enzyme increases SEC23A protein levels, potentially treating congenital anemia.
Dual stem cell therapy from fat tissue dramatically reduces limb amputation risk by rebuilding blood vessels in severe circulation disease.
Radiation triggers a Ca²⁺-NFATc1-Fis1 cascade that fragments mitochondria in bone marrow stem cells, halting bone repair — and silencing Fis1 reverses it.
