20 articles
New research shows brief fasting periods can boost the effectiveness of cancer immunotherapy by reshaping tumor-fighting immune cells.
Specific gut microbes produce compounds that reprogram fat cells to enhance immune responses against cancer.
A growth factor called GDF11 reprograms pro-tumor macrophages by rewiring their metabolism, suppressing hepatocellular carcinoma growth.
New research reveals how a high-fat diet rewires tumor-to-nerve communication, accelerating cachexia — the devastating wasting syndrome that kills cancer patients.
AML stem cells produce BHB via autonomous ketogenesis to block ferroptosis, revealing a targetable metabolic vulnerability in leukemia.
Redirecting glucose metabolism during T cell expansion dramatically improves cancer immunotherapy effectiveness.
Tumor-infiltrating adipocytes release a lipid metabolite that triggers neutrophil cell death, suppressing CD8+ T cells in pancreatic cancer.
New research reveals how tumors hijack brain pathways through GDF15 protein to cause devastating weight loss in cancer patients.
Cancer cells that downregulate SMC4 enter a low-proliferation, diapause-like state that resists standard chemotherapy, revealing a dangerous survival mechanism.
A lipid metabolism enzyme called SMPD1 anchors the deadliest cancer mutation to the cell membrane — and blocking it may finally crack KRAS.
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
Leukemic stem cells produce their own ketone bodies to block ferroptosis, revealing a metabolic weak point that could be targeted therapeutically.
GLP-1 receptor agonists may overcome Lenvatinib resistance in hepatocellular carcinoma by targeting a key glycolytic vulnerability.
Researchers respond to peer critique of risk-based, non-invasive hepatocellular carcinoma surveillance in metabolic liver disease patients.
Scientists discover how to reprogram cancer cells into harmless, non-dividing cells by targeting a nuclear enzyme pathway.
Researchers develop targeted drug that degrades FTO protein, disrupting ribosome production and protein synthesis in leukemia cells.
New research reveals how a specific protein causes anemia in myelodysplastic syndromes and predicts treatment response.
Ketogenic diet metabolite enhances CAR T cell metabolism and tumor control in multiple cancer models
Engineered magnetotactic bacteria delivered orally penetrate colorectal tumors, trigger immune attack, and reshape gut microbial metabolism in mice.
New research reveals how deadly thyroid cancer reprograms itself to escape natural killer cells, opening doors for better treatments.
