Flaxseed Lignans Boost Cancer Immunotherapy by Reshaping Gut Microbiome
Flaxseed compounds enhance PD-1 inhibitor effectiveness against breast cancer through gut bacteria modulation and immune system activation.
20 articles
Flaxseed compounds enhance PD-1 inhibitor effectiveness against breast cancer through gut bacteria modulation and immune system activation.
A clinical trial shows 4g/day icosapent ethyl nearly tripled marine omega-3 content in colorectal tissue, shifting the omega-3/omega-6 ratio favorably.
Researchers developed rat and mouse models mimicking early and middle stages of oral submucous fibrosis using bleomycin injections.
Ginsenoside Rh4 suppresses colorectal cancer by boosting Akkermansia muciniphila and elevating protective bile acid UDCA via FXR signaling.
Engineered magnetotactic bacteria delivered orally penetrate colorectal tumors, trigger immune attack, and reshape gut microbial metabolism in mice.
A growth factor called GDF11 reprograms pro-tumor macrophages by rewiring their metabolism, suppressing hepatocellular carcinoma growth.
Specific gut microbes produce compounds that reprogram fat cells to enhance immune responses against cancer.
New research reveals how successful chemotherapy creates special cells that enhance immune response and restrain tumor growth.
Retrospective study of 120 NSCLC patients finds thymalfasin plus chemoimmunotherapy significantly extends PFS and OS without added toxicity.
Researchers find that combining Ganoderma lucidum and Sanghuangporus vaninii extracts may fight colorectal cancer through vitamin D and Wnt pathways.
Spatial multi-omics reveals how specific fibroblasts create immunosuppressive environments that fuel colorectal cancer spread to the liver.
Comprehensive review reveals promising new drug targets and immunotherapy approaches for myelofibrosis beyond current JAK inhibitor limitations.
Fibrotic tissue stiffness activates a cascade that recruits immune cells and generates DNA-damaging aldehydes, linking dense breast tissue to cancer risk.
Tissue stiffness triggers a chain reaction — recruiting macrophages that generate DNA-damaging lipid byproducts — linking fibrosis directly to cancer initiation.
Scientists discover how two microbes team up to accelerate colon cancer, but L-arginine may disrupt their deadly partnership.
Massive spatial analysis reveals conserved fibroblast subtypes that control immune infiltration and therapy response across cancer types.
New study reveals how immune cells in tumors deliver protective proteins that block a promising cancer treatment approach.
New review reveals why fecal microbiota transplants sometimes help—and sometimes hurt—immune checkpoint inhibitor cancer treatments.
RSL3-induced ferroptosis degrades SHP2 via chaperone-mediated autophagy, amplifying IFN-γ/STAT1 signaling and enhancing anti-PD-1 immunotherapy efficacy.
Study identifies senescent EGR1+ B cells that sabotage immunotherapy in esophageal cancer, with fisetin showing promise as a therapeutic enhancer.