Longevity & Aging
Fisetin Fights Atherosclerosis by Rewiring Cholesterol Metabolism
A flavonoid found in strawberries activates a key nuclear receptor to slash cholesterol and reverse arterial plaque in mice.
Research Paper
May 4, 2026 0
Results for "Fisetin" in Advanced Therapies
20 articles
Longevity & Aging
Fisetin Supplements Reverse Age-Related Muscle Decline as Effectively as Genetic Senescent Cell Clearance
Intermittent fisetin dosing in old mice reduced frailty and boosted grip strength, matching results from genetic and synthetic senolytic approaches.
Research Paper
May 13, 2026 0
Longevity & Aging
Fisetin Fights Periodontitis by Shielding Fibroblasts from Oxidative Stress
A multiomics and network pharmacology study reveals fisetin reduces alveolar bone loss and protects periodontal fibroblasts from oxidative damage.
Research Paper
May 6, 2026 0
Longevity & Aging
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Zombie Cells: How Aging Cells Poison Their Neighbors
Discover how 'zombie cells' in your body send harmful signals that spread aging from cell to cell โ and what scientists are doing to stop them.
TutorialBeginner
Jun 17, 2026 0
Regenerative Medicine
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Senolytic Drugs: Clearing Out Zombie Cells to Reverse Aging
Discover how revolutionary drugs target 'zombie cells' that accumulate with age, potentially reversing aging and extending healthspan.
TutorialIntermediate
Apr 14, 2026 0
Longevity & Aging
Fisetin Targets Aging, Cancer, and Inflammation Through Multiple Pathways
A comprehensive review reveals fisetin's broad therapeutic potential spanning senescence, neurodegeneration, and cancer โ with key bioavailability hurdles to overcome.
Research Paper
May 8, 2026 0
Longevity & Aging
Liposomal Fisetin Suppresses Inflammatory SASP Without Killing Senescent Cells
Fisetin encapsulated in liposomes significantly reduces IL-6 and IL-8 secretion in senescent lung cells, revealing potent senomorphic but not senolytic activity.
Research Paper
May 18, 2026 0
Longevity & Aging
Fisetin Tested as Senolytic Treatment to Reduce COVID-19 Complications
A Phase 2 pilot trial investigates whether the natural senolytic compound fisetin can reduce dysfunction and complications in COVID-19 patients.
Clinical Trial
May 8, 2026 0
Longevity & Aging
Fisetin Clears Senescent Cells and Restores Blood Vessel Function via CXCL12
A new mouse study shows fisetin senolytic treatment reverses age-related endothelial dysfunction by eliminating senescent cells and reducing the SASP factor CXCL12.
Research Paper
May 18, 2026 0
Longevity & Aging
Fisetin and Quercetin Show Real Promise as Natural Senolytic Compounds
A 2026 review evaluates how two common dietary flavonoids target senescent cells, potentially slowing aging and age-related disease.
Research Paper
May 9, 2026 0
Longevity & Aging
Fisetin Plus Dapagliflozin Synergistically Reverses PCOS Markers in Rat Model
Combining the flavonoid fisetin with SGLT2 inhibitor dapagliflozin outperformed either drug alone in restoring hormones, reducing oxidative stress, and normalizing reproductive cycles in PCOS rats.
Research Paper
May 7, 2026 0
Longevity & Aging
Fisetin and Resveratrol Clear Senescent Cells in Arthritic Cartilage
Two natural compounds suppress cellular senescence in osteoarthritic cartilage progenitor cells, reducing inflammatory SASP markers via p53 pathway.
Research Paper
May 4, 2026 0
Longevity & Aging
Senolytic Drug Fisetin Reduces Atrial Fibrillation Risk in Aging Hearts
New research shows removing senescent cells with fisetin dramatically reduces dangerous heart rhythm disorders in aging rabbits.
Research Paper
Mar 29, 2026 2
Longevity & Aging
Fisetin and Chlorogenic Acid Shield Neurons from Alzheimer's Toxic Protein
Two natural polyphenols reverse amyloid-beta damage in human neurons by restoring mitochondrial health, autophagy, and synaptic function.
Research Paper
May 6, 2026 0
Longevity & Aging
Fisetin Targets NUF2 to Block Prostate Cancer Growth via p38/MAPK Pathway
Researchers identify NUF2 as a key driver of prostate cancer and discover fisetin, a natural compound, as a promising inhibitor of this oncogene.
Research Paper
May 7, 2026 0
Longevity & Aging
Four Flavonols Show Multi-Target Power Against Alzheimer's Pathology
Quercetin, kaempferol, myricetin, and fisetin each attack Alzheimer's through distinct molecular pathways, from amyloid clearance to neuroinflammation.
Research Paper
May 6, 2026 0
Longevity & Aging
New Synthetic Flavonol Clears Senescent Cells and Reverses Lung Fibrosis in Mice
A medicinal-chemistry optimized flavonol called F-4N shows 50ร greater senolytic potency than quercetin and resolves lung fibrosis in animal models.
Research Paper
Jun 16, 2026 0
Regenerative Medicine
Blocking Fis1 Restores Bone Formation After Radiation Therapy
Radiation triggers a Caยฒโบ-NFATc1-Fis1 cascade that fragments mitochondria in bone marrow stem cells, halting bone repair โ and silencing Fis1 reverses it.
Research Paper
May 6, 2026 0
Longevity & Aging
Senolytic Peptides Target FOXO4-p53 to Reverse Brain Aging and Memory Loss
A new class of retro-inverso peptides selectively destroys senescent brain cells via the FOXO4-p53 axis, restoring cognition in aged animal models.
Research Paper
May 4, 2026 0
Longevity & Aging
Plant Compound Isoquercitrin Fights Insulin Resistance by Blocking Cell Death Pathway
A natural flavonoid from traditional Chinese medicine may combat insulin resistance by inhibiting ferroptosis via the HIF-1ฮฑ/HO-1 signaling pathway.
Research Paper
May 8, 2026 0
Longevity & Aging
Senolytic Drugs Reshape Gut Bacteria in Ways That May Slow Aging
Four anti-aging compounds โ quercetin, fisetin, dasatinib, and sirolimus โ all shifted gut microbiome composition toward healthier aging profiles.
Research Paper
May 6, 2026 0
Longevity & Aging
Apigenin Blocks Liver Cell Death from Mold Toxin via Key Antioxidant Pathway
A natural plant flavonoid activates the Nrf2/FSP1 pathway to halt ferroptosis triggered by fumonisin B1, a common food contaminant.
Research Paper
Jun 5, 2026 0
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