20 articles
Radiation triggers a Caยฒโบ-NFATc1-Fis1 cascade that fragments mitochondria in bone marrow stem cells, halting bone repair โ and silencing Fis1 reverses it.
A novel class of ferroptosis inhibitors protects donor organs from ischemia-reperfusion injury, potentially saving thousands of transplant patients annually.
Single-cell sequencing reveals ferroptosis drives pulpitis; thymosin ฮฑ1 restores GPX4, cuts iron overload, and reduces inflammation in cells and rats.
ProcyanidinC1, a natural senolytic, selectively eliminates senescent cells in diabetic skin, dramatically improving wound healing in mouse models.
A senolytic pairing of dasatinib and quercetin cleared senescent cells at the tendon-bone junction, dramatically improving repair strength in aged rats.
Lab-grown skin organoids dramatically accelerated frostbite healing while preventing scar formation in mice.
Epicrispr's GEMS platform silences disease genes epigenetically โ reversibly and safely โ with a single viral vector, targeting FSHD and beyond.
Discover how revolutionary drugs target 'zombie cells' that accumulate with age, potentially reversing aging and extending healthspan.
New research shows GDF11 protein can prevent and treat steroid-induced bone death by activating blood vessel formation pathways.
New study suggests Lilly's tirzepatide leads to more lean muscle loss compared to Novo's semaglutide, despite superior weight loss results.
Three days of GDF11 infusion post-injury preserved pericytes, protected the blood-spinal cord barrier, and improved functional recovery in mice.
Scientists created ovarian support cells from stem cells that significantly improved egg maturation rates in fertility treatments.
A new technique called PIVOT enables single-cell functional genetic screens in plants, opening doors to precision crop and botanical medicine research.
A Phase 2 trial evaluates MBA-P01, a novel botulinum toxin A, for safety and optimal dosing in treating frown lines.
New combination therapy using stem cell exosomes and spirulina-based hydrogel shows promise for treating hard-to-heal diabetic wounds.
A 12-month RCT compares three scaffold types and two EDTA concentrations for regenerating necrotic immature permanent teeth.
Breakthrough treatment uses engineered immune cells to eliminate scar tissue and restore liver function in metabolic liver disease.
BIIB080 failed its primary endpoint in Phase 2, yet Biogen sees potential signals worth pursuing in the fight against Alzheimer's tau tangles.
Amgen expands late-stage testing of its long-acting obesity drug MariTide, including a trial for patients switching from rival GLP-1 medications.
A novel anti-swelling hydrogel loaded with dasatinib, quercetin, and nucleus pulposus exosomes clears senescent cells and restores disc integrity in rats and goats.
