Longevity & Aging
Fisetin Fights Atherosclerosis by Rewiring Cholesterol Metabolism
A flavonoid found in strawberries activates a key nuclear receptor to slash cholesterol and reverse arterial plaque in mice.
Research Paper
May 4, 2026 0
Results for "Fisetin"
20 articles
Longevity & Aging
Fisetin Supplements Reverse Age-Related Muscle Decline as Effectively as Genetic Senescent Cell Clearance
Intermittent fisetin dosing in old mice reduced frailty and boosted grip strength, matching results from genetic and synthetic senolytic approaches.
Research Paper
May 13, 2026 0
Longevity & Aging
Fisetin Fights Periodontitis by Shielding Fibroblasts from Oxidative Stress
A multiomics and network pharmacology study reveals fisetin reduces alveolar bone loss and protects periodontal fibroblasts from oxidative damage.
Research Paper
May 6, 2026 0
Longevity & Aging
Fisetin Targets Aging, Cancer, and Inflammation Through Multiple Pathways
A comprehensive review reveals fisetin's broad therapeutic potential spanning senescence, neurodegeneration, and cancer — with key bioavailability hurdles to overcome.
Research Paper
May 8, 2026 0
Longevity & Aging
Liposomal Fisetin Suppresses Inflammatory SASP Without Killing Senescent Cells
Fisetin encapsulated in liposomes significantly reduces IL-6 and IL-8 secretion in senescent lung cells, revealing potent senomorphic but not senolytic activity.
Research Paper
May 18, 2026 0
Longevity & Aging
Fisetin Clears Senescent Cells and Restores Blood Vessel Function via CXCL12
A new mouse study shows fisetin senolytic treatment reverses age-related endothelial dysfunction by eliminating senescent cells and reducing the SASP factor CXCL12.
Research Paper
May 18, 2026 0
Autoimmune & Arthritis
Fisetin Compound Boosts Cellular Cleanup to Fight Salmonella Infections
Natural flavonoid fisetin activates mitophagy and xenophagy pathways to restrict intracellular Salmonella growth in immune cells.
Research Paper
Apr 2, 2026 0
Longevity & Aging
Fisetin and Quercetin Show Real Promise as Natural Senolytic Compounds
A 2026 review evaluates how two common dietary flavonoids target senescent cells, potentially slowing aging and age-related disease.
Research Paper
May 9, 2026 0
Brain Health
Fisetin Targets Brain Inflammation in Alzheimer's Through CD44 Protein Pathway
Single-cell analysis reveals how the flavonoid fisetin may reduce neuroinflammation in Alzheimer's disease by targeting specific astrocyte subgroups.
Research Paper
Apr 2, 2026 0
Longevity & Aging
Fisetin Plus Dapagliflozin Synergistically Reverses PCOS Markers in Rat Model
Combining the flavonoid fisetin with SGLT2 inhibitor dapagliflozin outperformed either drug alone in restoring hormones, reducing oxidative stress, and normalizing reproductive cycles in PCOS rats.
Research Paper
May 7, 2026 0
Longevity & Aging
Fisetin and Resveratrol Clear Senescent Cells in Arthritic Cartilage
Two natural compounds suppress cellular senescence in osteoarthritic cartilage progenitor cells, reducing inflammatory SASP markers via p53 pathway.
Research Paper
May 4, 2026 0
Longevity & Aging
Senolytic Drug Fisetin Reduces Atrial Fibrillation Risk in Aging Hearts
New research shows removing senescent cells with fisetin dramatically reduces dangerous heart rhythm disorders in aging rabbits.
Research Paper
Mar 29, 2026 2
Longevity & Aging
Fisetin and Chlorogenic Acid Shield Neurons from Alzheimer's Toxic Protein
Two natural polyphenols reverse amyloid-beta damage in human neurons by restoring mitochondrial health, autophagy, and synaptic function.
Research Paper
May 6, 2026 0
Longevity & Aging
Fisetin Targets NUF2 to Block Prostate Cancer Growth via p38/MAPK Pathway
Researchers identify NUF2 as a key driver of prostate cancer and discover fisetin, a natural compound, as a promising inhibitor of this oncogene.
Research Paper
May 7, 2026 0
Longevity & Aging
Four Flavonols Show Multi-Target Power Against Alzheimer's Pathology
Quercetin, kaempferol, myricetin, and fisetin each attack Alzheimer's through distinct molecular pathways, from amyloid clearance to neuroinflammation.
Research Paper
May 6, 2026 0
Longevity & Aging
New Synthetic Flavonol Clears Senescent Cells and Reverses Lung Fibrosis in Mice
A medicinal-chemistry optimized flavonol called F-4N shows 50× greater senolytic potency than quercetin and resolves lung fibrosis in animal models.
Research Paper
Jun 16, 2026 0
Heart Health
Why Fenofibrate Outperforms Other Fibrates for Cardiovascular Risk
Not all fibrates work the same way — fenofibrate uniquely reduces apoB, cutting residual cardiovascular risk beyond statins alone.
Research Paper
Jun 6, 2026 0
Regenerative Medicine
Blocking Fis1 Restores Bone Formation After Radiation Therapy
Radiation triggers a Ca²⁺-NFATc1-Fis1 cascade that fragments mitochondria in bone marrow stem cells, halting bone repair — and silencing Fis1 reverses it.
Research Paper
May 6, 2026 0
Cancer Research
Senescent B Cells Drive Cancer Immunotherapy Resistance in Esophageal Cancer
Study identifies senescent EGR1+ B cells that sabotage immunotherapy in esophageal cancer, with fisetin showing promise as a therapeutic enhancer.
Research Paper
Apr 2, 2026 0
Longevity & Aging
Senolytic Peptides Target FOXO4-p53 to Reverse Brain Aging and Memory Loss
A new class of retro-inverso peptides selectively destroys senescent brain cells via the FOXO4-p53 axis, restoring cognition in aged animal models.
Research Paper
May 4, 2026 0
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