Brain Health
Simufilam Alzheimer's Trial Terminated Before Completing Phase 3
Cassava Sciences' 76-week Phase 3 trial of simufilam for Alzheimer's was terminated, raising questions about the drug's future.
Clinical Trial
Jun 1, 2026 0
Results for "Fisetin Senolytic" in Alzheimer's
20 articles
Brain Health
Dasatinib and Quercetin Reach the Brain in Early Alzheimer's Patients
A completed Phase 1/2 pilot trial tested whether the senolytic duo D+Q penetrates the brain in early Alzheimer's disease.
Clinical Trial
May 28, 2026 0
Brain Health
Gamma Interferon Pilot Trial Tests Frataxin Boost in Friedreich Ataxia Patients
A Phase 2 open-label trial explores whether an approved immune drug can raise frataxin protein levels and slow neurological decline in Friedreich Ataxia.
Clinical Trial
Jun 16, 2026 0
Brain Health
Microalgae Supplement BrainPhyt Shows Promise for Cognitive Health in Older Adults
24-week trial tested fucoxanthin-rich microalgae supplement on memory, attention, and executive function in 66 healthy seniors.
Clinical Trial
Mar 28, 2026 0
Brain Health
Flavonoid Supplement Shows Promise for Cognitive Function in Elderly Adults
Italian researchers test plant-based compounds for brain health and quality of life in aging adults with promising early results.
Clinical Trial
Mar 28, 2026 2
Brain Health
Fish Oil and Alpha Lipoic Acid Show Promise Against Alzheimer's Disease Progression
Small trial tested whether fish oil and alpha lipoic acid could slow Alzheimer's by reducing oxidative stress markers in blood.
Clinical Trial
Mar 28, 2026 1
Brain Health
First Human Trial of Oral D-Peptide Drug Targeting Alzheimer's Toxic Oligomers Completed
Contraloid acetate, an oral all-D-peptide designed to disassemble toxic amyloid-beta oligomers, completed its first-in-human safety trial in 40 healthy volunteers.
Clinical Trial
Jun 12, 2026 0
Brain Health
New Drug Shows Promise in Preventing Alzheimer's Amyloid Buildup in Young Adults
NGP 555 targets toxic brain protein production in healthy volunteers, offering potential early intervention for Alzheimer's prevention.
Clinical Trial
Mar 28, 2026 0
Brain Health
Retired Cholesterol Drug Shows Promise for Alzheimer's Prevention in Small Trial
Probucol, a discontinued cholesterol medication, may boost brain-protective proteins in older adults at risk for dementia.
Clinical Trial
Mar 29, 2026 0
Brain Health
Drugs That Boost Brain Waste Clearance During Sleep Show Promise Against Alzheimer's
A Phase 1/2 trial tests whether dexmedetomidine can enhance the brain's glymphatic system to clear amyloid and tau during sleep.
Clinical Trial
May 16, 2026 0
Brain Health
Nordic Berries Put to the Test for Fighting Age-Related Cognitive Decline
A completed trial tests whether daily Nordic berry beverages can sharpen cognition in healthy adults over 12 weeks.
Clinical Trial
Jun 14, 2026 0
Brain Health
BACE Inhibitor Atabecestat Trial in Pre-Symptomatic Alzheimer's Risk Terminated Early
A phase 2/3 trial of the BACE inhibitor atabecestat in amyloid-positive asymptomatic adults was terminated before completion, raising questions about this drug class.
Clinical Trial
May 13, 2026 0
Brain Health
CBT-I Therapy Targets Both Sleep and Alzheimer's Amyloid in Older Adults
A completed RCT tests whether treating insomnia with CBT-I can improve cognition and slow amyloid buildup in adults aged 60–85.
Clinical Trial
May 14, 2026 0
Brain Health
Time-Restricted Eating Shows Promise for Brain Health and Cognitive Performance
32-person study explores how intermittent fasting affects blood vessel function and brain performance through protective pathways.
Clinical Trial
Mar 29, 2026 1
Brain Health
Carnosine Supplement Targets Neuromuscular Decline in Multiple Sclerosis
A completed pilot trial tests whether 2g/day of a novel carnosine formulation can restore neuromuscular function and quality of life in MS patients.
Clinical Trial
Jun 17, 2026 0
Brain Health
Bioavailable Turmeric Supplement Tested Against Cognitive Decline in Metabolic Syndrome
The EPICURO trial tests MERIVA® turmeric over 6 months to see if it protects cognition in adults with metabolic syndrome.
Clinical Trial
May 7, 2026 0
Brain Health
Rapastinel Shows Lower Abuse Potential Than Ketamine in Phase 1 Trial
A completed Phase 1 trial compared the abuse liability of rapastinel versus ketamine in recreational polydrug users, with implications for safer depression treatment.
Clinical Trial
Jun 5, 2026 0
Brain Health
Actovegin Shows Promise for Cognitive Recovery After Stroke in Major Clinical Trial
Large 503-patient study tested whether Actovegin could improve thinking and memory problems that persist after stroke recovery.
Clinical Trial
Mar 28, 2026 0
Brain Health
Diabetes Drug Metformin Shows Promise for Parkinson's Disease Treatment
60-patient trial explores whether metformin, combined with standard therapy, could slow Parkinson's progression through metabolic pathways.
Clinical Trial
Mar 28, 2026 1
Brain Health
Alpha-Lipoic Acid Added to Flunarizine Tested for Teen Migraine Prevention
A completed Phase 4 trial from India evaluates whether ALA supplementation boosts flunarizine's migraine-prevention power in adolescents.
Clinical Trial
Jun 17, 2026 0
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