20 articles
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
Maastricht University investigated whether NA, NAM, and tryptophan together could restore mitochondrial function in physically compromised older adults.
Master the salvage, de novo, and Preiss-Handler pathways that maintain NAD+ levels and drive longevity interventions.
275-patient study tests novel liver-targeted therapy for NASH, a serious form of fatty liver disease affecting millions worldwide.
Daily anthocyanin supplementation helped over half of prediabetic participants return to normal glucose tolerance in just 12 weeks.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Enanta Pharmaceuticals tests its FXR agonist EDP-305 in a completed Phase 2 randomized trial for non-alcoholic steatohepatitis.
Updated review of anti-obesity medications in MASLD finds GLP-1 agonists reduce steatosis and fibrosis, while newer dual/triple agonists show even greater metabolic promise.
New research links NAD+ imbalance to RYR1-related muscle disorders, potentially revealing cellular aging pathways.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions โ for those who want the full mechanistic picture.
Sodium propionate reduced liver inflammation and fat accumulation in diabetic mice fed high-fat, AGE-rich diets through multiple protective mechanisms.
Novel GLP-1 analogue NNC5840 achieves greater weight reduction than semaglutide by optimizing receptor signaling bias rather than potency.
A landmark JCI review maps the expanding pharmacological arsenal for MASH, from GLP-1 agonists to triple receptor therapies and precision medicine.
Scientists identify an NADH-dependent molecular switch linking glycolysis to mitochondrial ATP synthesis, revealing a new metabolic control point.
Discover how NAD+ powers your cells and why this crucial molecule decreases as we age, plus practical ways to support healthy levels.
Deep dive into the master regulatory pathways controlling mitochondrial biogenesis, quality control, and cellular energy homeostasis through PGC-1ฮฑ coordination.
New research identifies choline kinase alpha as a key driver of diabetic retinopathy and microvascular dysfunction.
Go beyond the basics and explore the biochemical mechanisms behind glycation โ from the Maillard reaction cascade to RAGE signaling and tissue cross-linking โ to understand why AGEs are central to aging and metabolic disease.
Scientists discover vitamin B3 can target a key genetic driver of fatty liver disease, offering hope for a safe, accessible treatment.
Takeda's Phase 1 trial evaluates the safety and tolerability of TAK-510, a novel injectable agent targeting nausea and vomiting, across escalating doses.
