20 articles
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
A comprehensive review reveals how immunosenescence and chronic neuroinflammation create a self-reinforcing cycle that accelerates dopaminergic neuron loss in Parkinson's disease.
IRISeq maps gene expression across aging mouse brains, finding lymphocytes fuel neuroinflammation and accelerate cellular aging.
Scientists discover adult brain cells keep epigenetic memories from development that may fuel gliomas but also enhance regeneration.
Scientists uncover the molecular mechanisms driving microglial aging in the brain, offering insights into neurodegeneration.
Large study reveals when patients with MOG antibody disease can discontinue immunosuppressive therapy without relapse.
New research reveals that the molecular state of immature neurons in the aged hippocampus predicts cognitive resilience — not just their number.
A 9-day intranasal insulin regimen restored working memory, recognition memory, and reduced neuroinflammation in mice engineered to mimic hippocampal aging.
New single-nucleus RNA sequencing reveals immature neurons persist in aged human hippocampus and may actively support cognitive resilience in Alzheimer's disease.
New research reveals how immune cytokines IL-4 and IL-13 directly signal to brain neurons to regulate synapses and cognitive function.
Breakthrough study shows complete reversal of severe Alzheimer's symptoms in mice, identifying new therapeutic targets for human treatment.
New research reveals that gene therapy for SMA causes significant immune activation, suggesting immune dysfunction is central to the disease.
Scientists used stem cell-derived vesicles to deliver light-activated gene therapy to the brain without surgery, reversing cognitive decline in Alzheimer's mice.
New study reveals brain blood vessel aging as key driver of memory loss, with senolytic drugs showing promise for reversal.
Groundbreaking research shows neural anticipation of a virtual infection activates measurable immune responses, revealing a direct brain-immune axis.
Blocking brain lymphatic drainage triggers age-dependent compensatory responses — young rats adapt, middle-aged rats largely cannot, with proteomic signs of neurodegeneration in both.
New iPSC and cerebral organoid research shows HSV-1 directly activates neurodegeneration and senescence pathways, supporting the viral hypothesis of Alzheimer's disease.
Researchers identify RORA as a key driver of cataract formation by triggering oxidative damage and cell aging in the lens — and find a small-molecule inhibitor that may reverse it.
PEMFs repair mitochondrial damage and boost brain signaling pathways in stressed neurons, offering new therapeutic hope.
A landmark Nature Neuroscience study reveals how peripheral immune cells infiltrate the spinal cord in ALS, pointing to targeted immunotherapy.
