20 articles
A small trial found tocilizumab, an anti-inflammatory drug, cut depression remission rates better than SSRIs by targeting IL-6, not brain chemistry.
New compounds targeting the cPLA2 enzyme may reduce Alzheimer's-linked brain inflammation, especially in high-risk APOE4 gene carriers.
Recent NIA findings spotlight lifestyle factors cutting Alzheimer's risk by 60%, calorie restriction slowing aging, and a gene regulating plaque toxicity.
The SenNet atlas reveals where aging cells accumulate in human tissues, opening new doors for senolytic therapies and healthspan extension.
A molecule called OLE restores microglia's protective function, reducing amyloid plaques and improving memory in animal models.
Declining Menin in the hypothalamus drives inflammation and aging. Restoring it reversed decline; D-serine amino acid improved cognition in mice.
New brain-targeted gene therapy mimics morphine's pain relief while avoiding addiction, offering hope for 50+ million Americans with chronic pain.
Researchers turned ordinary brain cells into plaque-clearing machines, reducing Alzheimer's amyloid by half in mice with one treatment.
Blocking the protein PTP1B boosted memory and cleared brain plaque in mice, with potential links to diabetes and obesity treatment.
New research identifies FTL1 protein as key driver of brain aging. Reducing it restored memory and neural connections in mice.
A Cochrane review of 20,000+ patients finds amyloid-clearing drugs offer no meaningful benefit and raise brain bleed and swelling risks.
New mouse research finds the trendy D+Q senolytic combo severely damages myelin, raising red flags for longevity self-experimenters.
New research reveals five ways microscopic plastic particles could damage brain health and accelerate neurodegenerative diseases.
New research reveals how tiny plastic particles we consume daily could damage brain cells through five key biological pathways.
Duke researchers restored healthy mitochondria to damaged nerve cells, cutting pain-related behaviors by 50% in mice with nerve pain.
Three existing drugs, including a shingles vaccine, emerge as top candidates for repurposing against Alzheimer's disease.
Researchers finally discovered how lecanemab clears brain plaques by activating immune cells through a specific antibody fragment.
Major study identifies three existing drugs that could be repurposed to fight Alzheimer's disease, offering faster path to treatment.
Raising Sox9 levels in aging astrocytes reduced amyloid plaque buildup and protected memory in mouse models with existing Alzheimer's symptoms.
Researchers finally discovered lecanemab activates brain immune cells through a specific antibody fragment to clear toxic plaques.
