Brain's Waste-Clearance System Fails After Oxygen Deprivation at Birth
HIE disrupts the glymphatic system in neonatal brains, impairing waste clearance and development with lasting consequences.
20 articles
HIE disrupts the glymphatic system in neonatal brains, impairing waste clearance and development with lasting consequences.
Cerebral hypoperfusion drives glymphatic dysfunction in systemic inflammation โ and restoring blood flow with levosimendan reverses it.
A landmark review proposes a paradigm shift in neurocritical care, moving from static ICP thresholds to dynamic intracranial monitoring of autoregulation, glymphatics, and compliance.
Scientists discover how brain neurons regulate acute lung injury by controlling immune cell activity through the nervous system.
New research reveals how stress hormones can distort brain imaging results, potentially leading to misinterpretation of neural activity.
Research reveals concerning lung complications in MS patients treated with ocrelizumab, raising important safety questions.
New research reveals how stroke disrupts mitochondria and endoplasmic reticulum, offering targets for neuroprotection.
Six-week hypnotic cognitive therapy program significantly reduced pain intensity and depression in spinal cord injury patients.
New research explores how inhibiting brain orexin pathways could impact nicotine reward processing and fear-based memories.
Novel body-based therapy increased oxytocin levels by 46% and reduced psychological distress in medical professionals.
A randomized pilot study finds PEMF therapy significantly improved fatigue, sleep, depression, and walking capacity in post-COVID-19 patients over 5 weeks.
Simple compound successfully treats life-threatening COQ2 deficiency in newborn, offering hope for rare mitochondrial disorders.
New study reveals how emotional neglect in childhood impairs the ability to sense internal body signals in anorexia patients.
27-Hydroxycholesterol triggers microglial senescence through iron dysregulation, and the iron chelator deferoxamine reverses the damage.
A 5-year cohort study finds elevated blood palmitoleic acid โ a marker of excess energy intake โ accelerates brain hypometabolism linked to cognitive decline.
Nicotinamide riboside prevents moyamoya-like brain vessel blockages by fixing cellular energy production in smooth muscle cells.
After ischemic stroke, a mislocated brain water channel (AQP4) disrupts waste clearance. Blocking AQP4 with TGN-020 corrects its position and restores glymphatic flow.
Excessive vigorous exercise triggers a muscle-derived factor that acts as a mitochondrial imposter, impairing cognitive function.
Researchers respond to critiques of their trial showing positive airway pressure therapy may improve cognitive outcomes in Parkinson's disease.
Malaysian study shows mindfulness breathing meditation significantly improves cognitive flexibility and reduces stress in just 4 weeks.