20 articles
New cryo-EM structures reveal how LYCHOS protein senses cholesterol levels to regulate mTORC1 signaling, offering drug targets for aging.
Researchers analyzed 2,911 proteins in 50,506 people to create a frailty score that predicts disease risk and biological aging.
Flavo-Proxylane topical treatment plus ultrasound reduced skin laxity by 44% in people using weight loss medications.
A newly identified protein shields the liver from alcohol injury by bridging mitochondria and fat droplets to enhance fatty acid oxidation.
A newly identified mitochondrial NAD transporter in fat cells controls whether you develop obesity and insulin resistance as you age.
Large study reveals specific blood proteins can identify who will die from heart disease a decade before death occurs.
A completed Maastricht trial tests whether targeted protein and exercise can boost muscle protein synthesis before dialysis becomes necessary.
New research reveals how a key cellular protein prevents ferroptosis, a type of cell death implicated in aging and age-related diseases.
A newly identified mechanism shows how omega-3 fatty acids protect aging kidneys — and why low FFAR4 receptor expression accelerates kidney disease.
Discover how this powerful gut hormone controls hunger, blood sugar, and may hold keys to healthy aging.
Deep dive into GLP-1 receptor mechanisms, cAMP-PKA signaling cascades, and their role in metabolic health and longevity pathways.
Scientists discover how a hypothalamic calcium channel detects leucine from dietary protein to trigger satiety and drive weight loss.
Deep dive into uncoupling protein 1 mechanisms, sympathetic nervous system control, and therapeutic strategies for metabolic health and longevity.
Mice lacking the HDAC9 gene gained less fat with age, accumulated fewer senescent cells, and showed improved mitochondrial respiration in adipose tissue.
Major study of 255,000+ people shows optimal cardiovascular health dramatically reduces disease progression and mortality risk.
A new framework reveals how lactate and β-hydroxybutyrate team up across organs to regulate metabolism, mitochondria, and disease.
A Phase IIa trial explores whether the HIF-PHI drug daprodustat can safely replace EPO injections in hemodialysis patients with anemia.
Discover how sirtuins act as your cellular repair crew and learn practical ways to boost these powerful longevity proteins naturally.
A 6-month AI-driven personalized diet intervention cut BMI by 33% and reduced biological age by 8 years in morbidly obese patients.
New research reveals how RAP1A protein regulates liver blood vessel function and may influence fibrosis progression in chronic liver disease.
