20 articles
New research reveals how the longevity protein Klotho may protect against Alzheimer's disease, with Mediterranean diet potentially boosting levels.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
New research reveals normal Tau protein limits mitochondrial efficiency — its absence boosts energy output and stress resistance.
Researchers identify transthyretin (TTR) as a potential biomarker for postoperative cognitive dysfunction, offering new diagnostic hope.
New study identifies KCTD20 gene suppression as a potential therapeutic target for clearing harmful tau proteins in neurodegenerative diseases.
A newly identified TFEB-ATP6V0C axis in microglia controls alpha-synuclein clearance — and restoring it reduces Parkinson's pathology in mice.
A new metabolomics study links diet and exercise to blood pathway scores that track cognitive and physical decline across CN, MCI, and Alzheimer's stages.
A newly identified proteasome activator, PA200, clears toxic alpha-synuclein aggregates and maintains function even when standard protein-disposal systems fail.
A liver enzyme released during exercise may rejuvenate brain blood vessels and protect against cognitive decline and Alzheimer's pathology.
Boosting BNIP3 in muscle tissue extends fly lifespan and shields the brain from age-related degeneration via a muscle-brain signaling axis.
New research reveals how ubiquitin ligase COP1 suppresses brain inflammation by degrading c/EBPβ protein in microglia cells.
New research identifies specific blood markers that independently predict both physical frailty and cognitive decline.
New research reveals how context-dependent protein interactions regulate TDP-43 dysfunction in ALS and frontotemporal dementia.
Researchers identify RORA as a key driver of cataract formation by triggering oxidative damage and cell aging in the lens — and find a small-molecule inhibitor that may reverse it.
New research reveals APOE2, the longevity-linked gene variant, shields human neurons from aging damage through enhanced DNA repair — not just lipid metabolism.
A neuron-specific proteasome system governs tau pathology, with APOE4 carriers showing heightened vulnerability as this system declines with age.
Deleting or inhibiting astrocytic PERK restores the brain's glymphatic drainage system and dramatically reduces Aβ and tau pathology in AD mouse models.
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
Plasma BDNF levels predict sarcopenia risk and detailed walking biomechanics in 646 older adults, illuminating the brain–muscle axis.
A newly identified molecular chain reaction links tau aggregates to neuronal death, revealing ZBP1 as a promising therapeutic target in Alzheimer's disease.
