20 articles
New research reveals how the longevity protein Klotho may protect against Alzheimer's disease, with Mediterranean diet potentially boosting levels.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
New research identifies FTL1 protein as key driver of brain aging. Reducing it restored memory and neural connections in mice.
Go beneath the surface to explore how NF-κB signaling, IKKβ activation, and hypothalamic stem cell decline drive whole-body aging — and which interventions can slow the process.
A deep mechanistic exploration of how hypothalamic IKKβ/NF-κB signaling, htNSC exosomal communication, and multi-axis hormonal dysregulation drive systemic aging — plus cutting-edge therapeutic strategies.
New research reveals normal Tau protein limits mitochondrial efficiency — its absence boosts energy output and stress resistance.
Stanford researcher reveals how exercise, fasting, and sunlight trigger youthful blood proteins that rejuvenate aging organs.
Researchers identify transthyretin (TTR) as a potential biomarker for postoperative cognitive dysfunction, offering new diagnostic hope.
Scientists discover 65 metabolites linked to sleep-wake cycles in older men, revealing new pathways between circadian health and aging.
New research reveals how protein interactions and modifications control our 24-hour biological rhythms and disease risk.
New study identifies KCTD20 gene suppression as a potential therapeutic target for clearing harmful tau proteins in neurodegenerative diseases.
Dive into the molecular machinery behind lifelong brain health — from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.
Probucol, a discontinued cholesterol medication, may boost brain-protective proteins in older adults at risk for dementia.
Scientists discover how daily rest-activity rhythms influence hundreds of metabolic compounds in older women's blood.
A newly identified TFEB-ATP6V0C axis in microglia controls alpha-synuclein clearance — and restoring it reduces Parkinson's pathology in mice.
New research reveals how targeting cryptochromes, key circadian clock proteins, may offer breakthrough treatments for diabetes, cancer, and sleep disorders.
Dr. Rhonda Patrick reveals how sulforaphane, omega-3s, vitamin D, and magnesium trigger cellular stress responses that enhance longevity.
UCLA scientists discover why some neurons resist Alzheimer's better than others, revealing a natural protein cleanup system that could lead to new treatments.
A new metabolomics study links diet and exercise to blood pathway scores that track cognitive and physical decline across CN, MCI, and Alzheimer's stages.
Baylor scientists find tubulin redirects rogue brain proteins away from toxic aggregates, pointing to a novel neurodegenerative disease strategy.
