20 articles
New research explores using Klotho protein with stem cell-derived vesicles to treat acute kidney injury, potentially offering regenerative therapy.
New research reveals how thrombopoietin hormone establishes lifelong blood stem cell hierarchy in newborns.
Dasatinib + quercetin clears senescent kidney cells, restores anti-aging protein Klotho, and reverses transcriptional aging across multiple renal cell types.
New research reveals how a key protein's behavior changes during intestinal cell development, offering insights into tissue regeneration.
Mitochondria-targeted antioxidant polymer shows superior protection against liver transplant injury compared to standard treatments.
The transcription factor Lhx2 in liver stellate cells promotes regeneration and suppresses fibrosis via TGF-β and HGF pathways.
Go beyond the basics to understand the enzymes, signaling pathways, and cellular crosstalk that govern how your extracellular matrix ages — and what researchers are doing about it.
Discover the invisible framework that holds your body together — and why keeping it healthy is one of the most exciting frontiers in longevity science.
Discover how four tiny proteins can turn back the clock on aging cells — and what this means for the future of medicine and longevity.
Go beyond the basics to understand how Wnt ligands, receptor complexes, and beta-catenin destruction machinery orchestrate stem cell behavior — and why these mechanisms break down with age.
Harvard researchers identify a rare mesenchymal cell type that regenerates the thymus and boosts T cell immunity in aged animals.
New research in Nature Aging suggests tissue mechanical softness is a critical factor enabling cellular regeneration, with major implications for aging biology.
A pharmacological cocktail transiently activates reprogramming genes in senescent endothelial cells, restoring function and improving blood flow in aged mice.
Dihydrotestosterone treatment restored heart function in aging mice by activating DNA repair mechanisms and reducing inflammation.
A newly discovered immune pathway suppresses thymic regeneration post-damage — and blocking IL-18 may restore it.
Biomolecular condensates formed by liquid-liquid phase separation offer a new platform for clearing disease-causing proteins conventional drugs can't target.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
Master the cutting-edge molecular pharmacology of Wnt pathway modulation — from small-molecule β-catenin activators to senescence-driven inhibitor networks — and understand how researchers are translating these mechanisms into regenerative therapies.
New research reveals how LMNA gene mutations cause premature aging in heart cells by shortening protective telomeres.
New review reveals how plant-based compounds and stem cell therapies could eliminate aging cells and restore youthful function.
