20 articles
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
A completed trial tests whether diode laser treatment reduces TLR-4 in saliva, linking periodontal inflammation to systemic aging biology.
Discover how persistent low-grade inflammation drives the aging process and learn strategies to combat this silent threat to longevity.
Go beyond inflammaging basics to understand how aging reshapes immune cell populations, triggers the SASP, and locks the body into a state of chronic low-grade inflammation at the molecular level.
New research reveals mortality from this rare immune disorder varies by time, potentially improving treatment strategies.
BNT162b2 mRNA vaccine induces special immune cells that protect against severe illness and may slow aging-related decline.
A multi-biomarker study finds pwMS show accelerated thymic involution, senescent T cell expansion, and neuroinflammation linked to aging.
Breakthrough therapy targeting B cells demonstrates significant improvement in lupus symptoms with sustained benefits over one year.
A cluster randomized trial tests whether couples counseling plus stigma workshops can boost PrEP/ART uptake among young South African adults.
A German proof-of-concept trial tests whether a maximal five-class antiretroviral regimen can deplete latent HIV reservoirs.
Senescent cells drive cyst growth in ADPKD, and targeting them with senolytics or the aldose reductase inhibitor epalrestat delays disease progression.
Targeting immune diseases before symptoms appear can delay clinical onset by over two years, offering new prevention strategies.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
RA patients with interstitial lung disease show accelerated cellular aging markers — shorter telomeres and fewer mitochondrial DNA copies than RA patients without lung involvement.
Stanford researchers used modified immune proteins to enhance neurogenesis and cognitive function in aged mouse brains.
Large Hong Kong registry study tracked how well patients stayed on newer JAK inhibitors versus traditional TNF blockers for RA treatment.
Master the molecular architecture of complement dysregulation in aging — from regulatory protein biochemistry to cutting-edge therapeutic targets — and understand how precision interventions can restore balance without dismantling immunity.
Historical analysis reveals how colchicum has remained a cornerstone gout treatment for over 2,000 years of medical practice.
Systematic review reveals younger RA patients achieve higher remission rates and better outcomes with biologic therapies than older patients.
Major study shows evolving therapies reduced lung disease progression from 21% to 12% in systemic sclerosis patients over the past decade.
