iPSC-Derived Vesicles Enable Noninvasive Optogenetics to Halt Alzheimer's Progression
Scientists used stem cell-derived vesicles to deliver light-activated gene therapy to the brain without surgery, reversing cognitive decline in Alzheimer's mice.
20 articles
Scientists used stem cell-derived vesicles to deliver light-activated gene therapy to the brain without surgery, reversing cognitive decline in Alzheimer's mice.
PEMFs repair mitochondrial damage and boost brain signaling pathways in stressed neurons, offering new therapeutic hope.
New research reveals that gene therapy for SMA causes significant immune activation, suggesting immune dysfunction is central to the disease.
Researchers develop novel immunotherapy using modified brain cells to target Alzheimer's pathology directly in the brain.
Bilateral theta burst stimulation enhanced neural repair and restored function after stroke in non-human primates through multiple mechanisms.
Scientists used red blood cells to transport healthy mitochondria into diseased brain cells, showing promise for Parkinson's treatment.
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
Nicotinamide riboside prevents moyamoya-like brain vessel blockages by fixing cellular energy production in smooth muscle cells.
New peptide delivery system restores brain connections and memory function in Alzheimer's models, offering hope for treating cognitive decline.
Duke researchers restored healthy mitochondria to damaged nerve cells, cutting pain-related behaviors by 50% in mice with nerve pain.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
New research shows Hericium erinaceus can force neuroblastoma cells to differentiate into mature neurons while stopping their cancerous growth.
Microglia package healthy mitochondria into vesicles and deliver them to astrocytes, sharply reducing cognitive decline in tau-pathology mice.
Researchers combined ultrasound with gene therapy to treat Leigh syndrome, significantly extending survival in mouse models.
Promising Cerebrolysin research for rare neurological disorder withdrawn, highlighting research integrity concerns.
Completed study of 102 older adults tested whether combined interventions can preserve brain volume and improve mobility through muscle-brain axis.
A molecule called OLE restores microglia's protective function, reducing amyloid plaques and improving memory in animal models.
Researchers built a machine learning imaging pipeline to detect cerebral microhemorrhages and tested SS-31 (elamipretide) in aged hypertensive mice.
Researchers turned ordinary brain cells into plaque-clearing machines, reducing Alzheimer's amyloid by half in mice with one treatment.
A landmark Nature Neuroscience study reveals how peripheral immune cells infiltrate the spinal cord in ALS, pointing to targeted immunotherapy.