20 articles
60-patient trial explores whether metformin, combined with standard therapy, could slow Parkinson's progression through metabolic pathways.
A 9-day intranasal insulin regimen restored working memory, recognition memory, and reduced neuroinflammation in mice engineered to mimic hippocampal aging.
A new study warns that diabetes medications could confound Alzheimer's biomarker studies, distorting our understanding of the diabetes-dementia link.
Dr. Sinclair explains the cellular mechanisms of aging and shares practical strategies to activate your body's natural longevity pathways.
A Phase 3 trial investigates whether the GLP-1 drug liraglutide can slow cognitive decline in T2DM patients at elevated Alzheimer's risk.
A new oral GLP-1 receptor agonist penetrates the brain, restoring astrocyte-neuron metabolic crosstalk disrupted in Alzheimer's disease.
A deep mechanistic exploration of how hypothalamic IKKΞ²/NF-ΞΊB signaling, htNSC exosomal communication, and multi-axis hormonal dysregulation drive systemic aging β plus cutting-edge therapeutic strategies.
A completed Mount Sinai RCT tested whether HBOT can improve brain blood flow and cognition in diabetic elders with mild cognitive impairment.
New research reveals how melatonin prevents harmful protein aggregation linked to both type 2 diabetes and brain degeneration.
New research identifies FTL1 protein as key driver of brain aging. Reducing it restored memory and neural connections in mice.
Stanford researchers find pioglitazone and liraglutide improve CNS insulin signaling, measured via neuron-derived vesicles in blood.
Italian researchers test plant-based compounds for brain health and quality of life in aging adults with promising early results.
Boosting BNIP3 in muscle tissue extends fly lifespan and shields the brain from age-related degeneration via a muscle-brain signaling axis.
A Phase 1/2 trial tests whether dexmedetomidine can enhance the brain's glymphatic system to clear amyloid and tau during sleep.
Completed study of 102 older adults tested whether combined interventions can preserve brain volume and improve mobility through muscle-brain axis.
Declining Menin in the hypothalamus drives inflammation and aging. Restoring it reversed decline; D-serine amino acid improved cognition in mice.
Dive into the molecular machinery behind lifelong brain health β from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.
New research reveals how the longevity protein Klotho may protect against Alzheimer's disease, with Mediterranean diet potentially boosting levels.
180-person study explores whether Mediterranean eating patterns can prevent cognitive decline in overweight seniors.
Go beneath the surface to explore how NF-ΞΊB signaling, IKKΞ² activation, and hypothalamic stem cell decline drive whole-body aging β and which interventions can slow the process.
