Insulin Resistance in Aging Is a Whole-Body Failure, Not Just a Blood Sugar Problem
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
20 articles
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
A Cochrane review of 37 RCTs finds obesity drugs modestly reduce weight in adolescents, but evidence quality is low and long-term data are absent.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
Longevity experts endorse CGMs for metabolic optimization, but RCT evidence in non-diabetics is still thin.
A landmark review reveals how sustained glucocorticoid exposure drives aging biology โ and what can be done about it.
Continuous glucose monitors are popular in biohacking circles, but direct evidence linking CGM use to extended lifespan remains thin.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.
Expert reviews compare leading senolytic and NAD+ supplement brands on ingredients, evidence quality, and value.
Expert reviews rank fisetin and quercetin as top senolytics, with spermidine and resveratrol as supporting players in longevity supplement stacks.
Expert reviews of top CGM platforms reveal genuine metabolic insights โ but no proof they extend lifespan in healthy adults.
Aging disrupts gut microbiota and mTOR signaling, crippling vaccine responses โ but targeted interventions may reverse this.
Top longevity doctors endorse CGMs for healthy adults, but evidence is mixed. Here's what the 2026 device reviews reveal.
Six leading CGM platforms compared on accuracy, evidence quality, and longevity claims โ most fall short of the hype.
Dexcom G7 tops expert picks for metabolic biohacking, but evidence for non-diabetics remains mixed. Here's what the data says.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
Expert reviews compare top CGMs for longevity use, but evidence for healthy adults remains limited. Here's what you need to know.
Longevity experts endorse short CGM trials for non-diabetics, but RCT evidence remains thin. Here's what the data actually shows.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
A product review breaks down the evidence tiers for four popular longevity supplements and rates the best commercial stacks.