6 articles
Dr. Nir Barzilai presents his landmark centenarian studies and the FAST aging initiative, outlining the future of geromedicine.
Dr. Nir Barzilai outlines existing FDA-approved drugs with geromedicine potential and shares insights from decades of centenarian research.
A comprehensive review reveals metformin's polypharmacological mechanisms—from AMPK activation to gut microbiome remodeling—that may delay aging and enhance cancer immunotherapy.
Master the advanced molecular architecture of AMPK — from isoform-specific signaling and spatial compartmentalization to emerging pharmacological strategies targeting the energy sensor at the heart of longevity biology.
A major review challenges the evidence behind metformin as a longevity drug, exposing methodological flaws in landmark studies.
A deep mechanistic exploration of mTOR complex architecture, allosteric regulation, and the cutting-edge therapeutic strategies targeting this pathway for healthspan extension.
