Metformin Reverses a Key Aging Driver in the Small Intestine
A primate single-nucleus study identifies NCoR1 decline as a conserved gut aging mechanism โ and shows metformin can restore it.
20 articles
A primate single-nucleus study identifies NCoR1 decline as a conserved gut aging mechanism โ and shows metformin can restore it.
A completed clinical trial tests whether a prebiotic blend can boost Akkermansia muciniphila and support weight management in metabolic syndrome.
Fecal transplants from cancer survivors significantly improved treatment outcomes for metastatic kidney cancer patients.
A double-blind RCT finds FMT capsules added to escitalopram reduce depression scores faster via bile acid and anti-inflammatory pathways.
A precision nutrition trial finds liver insulin resistance responds to dietary fat changes via gut microbiota shifts, while muscle IR does not.
Small pilot study tests whether resistant starch from potatoes can safely modify gut bacteria in cancer patients receiving dual checkpoint inhibitors.
Bacterial metabolite from flavonoids protects against graft-versus-host disease while preserving anti-cancer effects in stem cell transplants.
Fecal microbiota transplants dramatically improved immune checkpoint inhibitor response rates in lung cancer and melanoma patients.
A completed trial explores whether a low-fibre diet can ease intestinal dysmotility โ one of the most debilitating but overlooked symptoms of mitochondrial disease.
Research finds the absorption enhancer in oral semaglutide tablets affects gut bacteria and inflammation markers beyond its intended role.
GOULASH trial compares feeding strategies for pancreatitis patients to optimize recovery outcomes.
Major review reveals how specific gut microbes influence insulin resistance and offers new targets for diabetes prevention.
Clinical trial tests safety of combined prebiotic-probiotic supplement in 32 healthy participants over 5 months.
A common oat fiber supercharges anti-PD-1 checkpoint therapy by expanding a key gut microbe that produces immune-activating metabolites.
A formal correction notice has been issued for the 2025 IMPACT BCN trial subanalysis examining Mediterranean diet and Mindfulness-Based Stress Reduction effects on maternal microbiota during pregnancy.
Real-world Australian study shows promising results for teduglutide in reducing dependency on IV nutrition in short bowel syndrome patients.
A completed pilot trial explores whether a cholesterol-lowering probiotic can improve cardiometabolic health in people with celiac disease.
A prospective clinical study examines how gastric bypass alters gut bacteria, appetite hormones, and metabolic health in 60 severely obese patients.
New research in Cell Metabolism explores how gut bacteria and their metabolites regulate immune checkpoint blockade efficacy in cancer patients.
New research shows how gut bacteria patterns can guide personalized diet strategies, potentially improving metabolic syndrome outcomes.