20 articles
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
Indole compounds from gut microbes reduce meth-induced depression and anxiety through brain receptor signaling.
Case study shows how methylmalonic acidemia disrupts dopamine pathways, causing severe movement disorders in adults.
A streamlined mass spectrometry assay detects preclinical Alzheimer's from just 100 µL of blood with AUC 0.81 vs 0.65 for previous methods.
Researchers built a machine learning imaging pipeline to detect cerebral microhemorrhages and tested SS-31 (elamipretide) in aged hypertensive mice.
A study of 991 blood metabolites finds ergothioneine has the strongest association with cognition, and antacid use may deplete it.
A Danish double-blind RCT tests a novel at-home electromagnetic field headband against sham for moderate-to-severe depression over 8 weeks.
12-week mindfulness exercise program significantly improved motor tics, anxiety, and daily functioning in 121 children with Tourette syndrome.
Emergency case study shows how brain imaging helps diagnose life-threatening metabolic crisis in alcohol-related emergency.
First 7T MRI study reveals distinct brain chemistry differences between ME/CFS and long COVID patients despite similar fatigue symptoms.
New inflammatory markers could help doctors differentiate between methamphetamine-induced psychosis and schizophrenia using simple blood tests.
Scientists develop pathway-selective drug that activates beneficial brain receptors while avoiding negative feedback loops.
AI-driven study identifies α-amyrin from fruits and vegetables as a promising Alzheimer's treatment that protects mitochondria and reduces tau tangles.
PEMFs repair mitochondrial damage and boost brain signaling pathways in stressed neurons, offering new therapeutic hope.
New research reveals how environmental manganese toxicity activates cellular immune sensors, leading to oxidative stress and neuronal death.
Nicotinamide riboside prevents moyamoya-like brain vessel blockages by fixing cellular energy production in smooth muscle cells.
Synthetic peptide chimeras degrade amyloid-beta across the blood-brain barrier, improving cognition in mice with fewer risks than current immunotherapies.
A brain-penetrant compound targets a key region of TDP-43, reducing motor neuron loss and extending survival in ALS mouse models.
New molecular mapping technique identifies individuals uniquely and predicts cognitive decline more accurately than standard brain scans.
Scientists image NMDA receptors at atomic resolution, uncovering how calcium enters and magnesium blocks the channel underlying neuroplasticity.
