20 articles
New technique uses cerebrospinal fluid to decode methylation signatures in children's brain tumors, potentially improving diagnosis.
Engineered magnetotactic bacteria delivered orally penetrate colorectal tumors, trigger immune attack, and reshape gut microbial metabolism in mice.
Cambridge scientists engineer a nanoprobe that detects therapy-induced senescence non-invasively through a simple urine colorimetric test.
Specific bacterial metabolic pathways in the gut determine whether cancer immunotherapy works by controlling immune responses.
Scientists develop bacteria that colonize tumors and secrete proteins to highlight cancer tissue with 15x better contrast than current methods.
Inhibiting the mitophagy kinase PINK1 amplifies mitochondrial ROS, activating a BAX-caspase-GSDME cascade that destroys neuroblastoma cells via pyroptosis.
Phase I trial of Temab-A reports 15.6% response rate and 74.6% disease control in heavily pretreated metastatic colorectal cancer patients.
Researchers analyzed 1,294 blood samples to create a comprehensive cancer detection method using cell-free DNA patterns.
Widely-used anesthetic triggers immune system to attack tumors and enhances checkpoint inhibitor therapy effectiveness.
Engineered green tea compound nanoparticles activate cellular powerhouses to suppress tumor growth and improve immune response against melanoma.
New ColonTrack model identifies early-stage colorectal cancer with 94% accuracy using three proteins from blood-based extracellular vesicles.
New blood test identifies early-stage breast and lung cancers by measuring epigenetic chaos in cell-free DNA fragments.
New liquid biopsy combining DNA methylation and protein markers shows promise for early multi-cancer detection across nine major cancer types.
Removing dietary copper starves leukemia cells of nucleotide building blocks, boosting methotrexate efficacy against hard-to-treat CNS disease.
Scientists develop brain-penetrating drug that makes glioblastoma cells vulnerable to targeted elimination therapy.
A gut metabolite produced after chemo reprograms bone marrow immune cells, creating a lasting shield against colorectal cancer liver metastasis.
A tryptophan-derived gut metabolite suppresses colorectal cancer by blocking a key glycolysis enzyme via STAT3 inhibition.
Novel nanoplatform delivers copper and iron ions to trigger both ferroptosis and cuproptosis in cancer cells.
New liquid biopsy analyzes DNA fragments in blood to detect breast cancer early, determine subtypes, and assess lymph node spread.
Comprehensive review reveals multiple resistance mechanisms and promising therapeutic approaches to improve outcomes for brain cancer patients.
