Blood DNA Methylation Score Predicts Cognitive Ability and MCI Risk
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
20 articles
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
Indole compounds from gut microbes reduce meth-induced depression and anxiety through brain receptor signaling.
A Phase 2 trial investigates whether thiethylperazine, a decades-old antiemetic, can flush toxic amyloid beta from the brains of early AD patients.
A Phase 1/2 trial tests whether dexmedetomidine can enhance the brain's glymphatic system to clear amyloid and tau during sleep.
A Phase 1 trial examines how gadobutrol moves through and exits the bodies of newborns and toddlers undergoing routine contrast MRI.
Dr. Glen Jeffery reveals how long-wavelength light passes through skin and clothing to enhance cellular energy production.
Case study shows how methylmalonic acidemia disrupts dopamine pathways, causing severe movement disorders in adults.
A streamlined mass spectrometry assay detects preclinical Alzheimer's from just 100 µL of blood with AUC 0.81 vs 0.65 for previous methods.
Researchers built a machine learning imaging pipeline to detect cerebral microhemorrhages and tested SS-31 (elamipretide) in aged hypertensive mice.
A study of 991 blood metabolites finds ergothioneine has the strongest association with cognition, and antacid use may deplete it.
A Danish double-blind RCT tests a novel at-home electromagnetic field headband against sham for moderate-to-severe depression over 8 weeks.
12-week mindfulness exercise program significantly improved motor tics, anxiety, and daily functioning in 121 children with Tourette syndrome.
Emergency case study shows how brain imaging helps diagnose life-threatening metabolic crisis in alcohol-related emergency.
MIT's self-organizing laser creates ultra-sharp brain images 25x faster, enabling real-time tracking of drugs crossing the blood-brain barrier.
First 7T MRI study reveals distinct brain chemistry differences between ME/CFS and long COVID patients despite similar fatigue symptoms.
New inflammatory markers could help doctors differentiate between methamphetamine-induced psychosis and schizophrenia using simple blood tests.
Scientists develop pathway-selective drug that activates beneficial brain receptors while avoiding negative feedback loops.
A completed trial tests EGCG combined with diet, exercise, and cognitive training to slow decline in ApoE4 carriers with early warning signs.
AI-driven study identifies α-amyrin from fruits and vegetables as a promising Alzheimer's treatment that protects mitochondria and reduces tau tangles.
UCL neuroscientist reveals how red light enhances cellular function and why common LED bulbs may be harming your health.