20 articles
A comprehensive review reveals methylene blue's expanding role from toxicology emergencies to perioperative care, neurology, and oncology.
Current labeling urges nursing mothers to pause breastfeeding for 8 days after methylene blue, but the underlying evidence is thin.
FDA-approved methylene blue reduced delirium-like behavior in surgical mice by suppressing neuroinflammation and repairing the blood-brain barrier.
A meta-analysis of 15 studies finds methylene blue therapy significantly reduces mortality in ICU septic shock patients, with hemodynamic benefits.
A 2025 review examines how methylene blue's nitric oxide inhibition can restore vascular tone in septic and vasoplegic shock patients.
A primate study shows methylene blue treats fatal cerebral malaria and uncovers neutrophil-linked genes as diagnostic biomarkers.
A 566-patient multicenter RCT launching across China to determine if early methylene blue reduces 28-day mortality in high-dose vasopressor-dependent septic shock.
A 200-patient study finds early methylene blue use in post-bypass vasoplegic shock halves ICU stays and reduces kidney failure rates.
A case report from Surrey and Sussex NHS Trust highlights risks of methylene blue extravasation into hand and forearm during parathyroid surgery.
A comprehensive review reveals how advanced oxidation processes can efficiently degrade methylene blue, a persistent textile pollutant threatening human health.
Adding methylene blue to ropivacaine in a serratus anterior plane block significantly prolongs pain relief up to 72 hours post-op.
New research shows blue light triggers harmful changes in retinal cells by disrupting mitochondrial function, offering targets for AMD prevention.
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
A 4-week-old infant developed severe methemoglobinemia after EMLA cream was applied for circumcision, highlighting hidden dangers of topical anesthetics.
Morning blue light exposure stabilized attention during cognitive tasks, reducing moment-to-moment mental variability in young adults.
A 303-tumor study shows DNA methylation arrays can classify neuroblastoma into prognostically meaningful subgroups, potentially replacing multiple genomic tests.
Cyanidin-3-O-glucoside, a natural anthocyanin, reduces immunosuppressive Tregs and slows multiple myeloma growth in mice and cell studies.
Delphinidin, a natural anthocyanin, prevented microglial senescence via AMPK/SIRT1 signaling, reducing amyloid plaques and restoring cognition in AD mice.
A comprehensive 2025 review details how gene therapy, transplant advances, and newborn screening are reshaping outcomes for this fatal brain disease.
New technique uses cerebrospinal fluid to decode methylation signatures in children's brain tumors, potentially improving diagnosis.
