20 articles
Microglia package healthy mitochondria into vesicles and deliver them to astrocytes, sharply reducing cognitive decline in tau-pathology mice.
Simple compound successfully treats life-threatening COQ2 deficiency in newborn, offering hope for rare mitochondrial disorders.
Scientists developed mitoDREADD-Gs, a novel tool that restores cognitive function by enhancing mitochondrial activity in mouse models of dementia.
A new mechanism links mitochondrial DNA trafficking through lysosomes to gasdermin-driven pyroptosis, with Parkinson's disease genes playing a key role.
New research reveals how electroacupuncture helps stroke recovery by promoting transfer of healthy mitochondria from support cells to damaged neurons.
Large study finds genetic background doesn't explain mitochondrial damage in neurodegenerative disease, pointing to complex causes.
Nicotinamide riboside prevents moyamoya-like brain vessel blockages by fixing cellular energy production in smooth muscle cells.
A new review reveals that disrupted mito-nuclear signaling may precede amyloid and tau pathology, opening fresh therapeutic targets for Alzheimer's.
New research reveals mitochondrial dysfunction as the starting point of Alzheimer's disease, offering early intervention targets.
New research reveals how stroke disrupts mitochondria and endoplasmic reticulum, offering targets for neuroprotection.
New review reveals how protein clumps and cellular powerhouses work together to drive neurodegeneration in Parkinson's disease.
Cryo-EM reveals VPS13A and scramblase XK work together to ferry lipids across organelle contact sites, unlocking a fundamental cell biology mystery.
Excessive vigorous exercise triggers a muscle-derived factor that acts as a mitochondrial imposter, impairing cognitive function.
Researchers combined ultrasound with gene therapy to treat Leigh syndrome, significantly extending survival in mouse models.
New research reveals how TDP-43 protein causes energy failure in motor neurons, pointing to potential metabolic therapies for ALS.
New research maps how mitochondrial damage and synaptic breakdown drive age-related hearing and balance loss in tandem.
MIT researchers map how ABCA7 loss-of-function variants wreck phosphatidylcholine metabolism and mitochondria in neurons — and find a potential fix.
A surprising new role for brain immune cells: microglia orchestrate glucose delivery to fuel memory-forming protein synthesis in active neurons.
Case study shows how methylmalonic acidemia disrupts dopamine pathways, causing severe movement disorders in adults.
Scientists used stem cell-derived vesicles to deliver light-activated gene therapy to the brain without surgery, reversing cognitive decline in Alzheimer's mice.
