Muscle Mitochondrial Defects Mapped as Root Cause of Genetic Insulin Resistance
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
20 articles
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
A completed OSU trial investigates whether short-term exercise training can restore impaired mitochondrial cleanup pathways in overweight and obese skeletal muscle.
Maastricht University investigated whether NA, NAM, and tryptophan together could restore mitochondrial function in physically compromised older adults.
Small pilot study explored whether platelets could serve as biomarkers for detecting mitochondrial problems linked to diabetes development.
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
New study reveals how endurance exercise transforms fat-burning brown adipose tissue in just six weeks of training.
UCSF study reveals how metformin and trimethoprim interfere with thiamine uptake, potentially affecting energy metabolism.
Clinical trial tested whether metformin could enhance resistance training benefits for muscle mass and strength in older adults.
Swiss researchers studied how mTOR protein in fat tissue affects metabolism and insulin function throughout the body.
Wake Forest study explores whether the diabetes drug metformin can trigger cellular changes linked to longevity in healthy people.
A Phase 2 trial tests a GalNAc-conjugated antisense therapy in familial partial lipodystrophy patients with dangerously high triglycerides.
20-week study reveals how sequencing HIIT and resistance training affects metabolic health in women with morbid obesity.
Study reveals how lean people can still have obesity-like metabolism and whether calorie restriction helps reverse this dangerous condition.
A completed RCT tests whether small-sided football sessions 3x/week improve glucose control and metabolic health in T2DM patients on GLP-1 and SGLT2 drugs.
Researchers mapped how anesthetics, nitric oxide, and other drugs alter hemoglobin's grip on oxygen โ with real implications for critical care.
275-patient study tests novel liver-targeted therapy for NASH, a serious form of fatty liver disease affecting millions worldwide.
A completed Maastricht trial tests whether targeted protein and exercise can boost muscle protein synthesis before dialysis becomes necessary.
Mediterranean diet, resistance training, and diabetes medication combined to combat sarcopenia and improve metabolic health in older adults.
Carmot Therapeutics tests CT-868, a novel dual incretin receptor agonist, for HbA1c reduction in overweight and obese adults with poorly controlled T2DM.
New research shows high-intensity interval training just once per week can improve obesity and fatty liver disease over a full year.