Heart Ventricles Adapt Differently to Mitochondrial Calcium Overload
New study reveals left ventricle recovers from mitochondrial stress while right ventricle remains vulnerable
20 articles
New study reveals left ventricle recovers from mitochondrial stress while right ventricle remains vulnerable
Deleting GTPBP3 in endothelial cells blocks angiogenesis via mtROS overload โ and a mitochondria-targeted antioxidant reverses the damage.
Review reveals how NAD+ precursors like NMN could restore heart function by fixing cellular energy production and reducing oxidative damage.
The first disease-specific treatment for Barth syndrome gains FDA accelerated approval, targeting mitochondrial dysfunction to restore muscle strength.
A mitochondrial enzyme found upregulated in pulmonary hypertension patients triggers vascular damage through a noncanonical mechanism โ and a known drug can block it.
Scientists uncover how faulty glycogen-priming proteins cause progressive cardiomyopathy, pointing toward gene therapy and autophagy as future treatments.
New review reveals how heart muscle energy production fails to match mechanical demands, driving different types of heart failure.
A newly discovered mitochondrial protein boosts cardiac glucose burning and dramatically reduces heart injury after ischemia-reperfusion.
Scientists map a precise molecular chain linking falling NAD levels to lysosomal dysfunction, cardiolipin loss, and age-related heart failure โ and show NAD restoration can reverse it.
Natural isoflavone prevents cardiac enlargement through novel mitochondrial protection pathway, offering new therapeutic approach.
Cas13-based RNA editing shows promise for treating hereditary hypertrophic cardiomyopathy by correcting disease-causing mutations at the RNA level.
New research reveals how 850nm infrared light exposure to the body enhances mitochondrial function and improves color perception.
Updated guidelines for transferring heart attack patients to specialized centers focus on optimal timing for life-saving procedures.
Novel liposome therapy delivers miR-10a to atherosclerotic plaques, reprogramming inflammatory macrophages and reducing disease progression in mice.
A pilot trial explores whether intentionally inducing brief daily dyssynchrony via pacemaker can retrain failing heart muscle in humans.
A sirtuin enzyme prevents heart scarring by keeping cardiac fibroblasts from switching to a pro-fibrotic metabolic state.
New genetic approach could revolutionize how we develop heart medications, potentially saving billions in failed drug trials.
A landmark Phase 3 trial evaluates whether omecamtiv mecarbil, a cardiac myosin activator, reduces cardiovascular death in HFrEF patients.
Scientists discover how damaged heart cells transform into new blood vessels, potentially revolutionizing heart failure treatment.
New research reveals how PINK1-mediated mitophagy protects against heart failure by preventing inflammatory DNA release from damaged mitochondria.