20 articles
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
A completed OSU trial investigates whether short-term exercise training can restore impaired mitochondrial cleanup pathways in overweight and obese skeletal muscle.
A Phase 1/2 trial of NFS-02 gene therapy for LHON-associated vision loss was terminated before completion, raising questions about mitochondrial gene therapy.
A completed trial explores whether a low-fibre diet can ease intestinal dysmotility — one of the most debilitating but overlooked symptoms of mitochondrial disease.
Maastricht University investigated whether NA, NAM, and tryptophan together could restore mitochondrial function in physically compromised older adults.
DuoStim lets women with poor ovarian reserve collect more eggs in one cycle, potentially cutting time to a successful pregnancy.
Small pilot study explored whether platelets could serve as biomarkers for detecting mitochondrial problems linked to diabetes development.
A completed University of Kansas trial investigates whether creatine monohydrate can support brain energy metabolism in Alzheimer's patients.
A phase 1 dose-escalation trial tests the safety of AAV-delivered ND4 gene therapy in patients with Leber's hereditary optic neuropathy.
University of Florida researchers tested whether resveratrol supplements could improve mitochondrial function and physical performance in seniors.
A pilot trial explores whether intentionally inducing brief daily dyssynchrony via pacemaker can retrain failing heart muscle in humans.
Completed study of 102 older adults tested whether combined interventions can preserve brain volume and improve mobility through muscle-brain axis.
Small study reveals BDNF genetic variant could influence exercise's cognitive and cardiovascular benefits in healthy men.
A landmark Phase 3 trial evaluates whether omecamtiv mecarbil, a cardiac myosin activator, reduces cardiovascular death in HFrEF patients.
Study reveals how neuromuscular electrical stimulation enhances training benefits beyond traditional exercise alone.
65-patient trial tested bone marrow stem cells injected directly into damaged heart muscle to restore function in chronic heart failure.
Clinical trial explores whether resetting gut microbiome through fecal transplants can slow Parkinson's progression and reduce symptoms.
A completed Maastricht University trial tests whether pairing NR supplementation with exercise can boost NAD+ levels and reverse metabolic dysfunction in overweight adults.
A Phase 1/2 trial tests whether nicotinamide riboside can restore NAD+ balance and improve heart function in systolic HF patients.
New trial explores whether short-term testosterone treatment creates lasting muscle benefits in older men through epigenetic memory.
