79 articles
A comprehensive review reveals how aging and disturbed blood flow reprogram endothelial cell metabolism, fueling atherosclerosis through glycolytic, lipid, and mitochondrial dysregulation.
A landmark review synthesizes 12 hallmarks of aging, emerging gerotherapeutics, and a new three-tier clinical care model to shift medicine from disease treatment to aging prevention.
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
Elevated CD38 in monocytes depletes NAD+ and fuels fibrosis in myeloproliferative neoplasms — blocking CD38 or boosting NAD+ may reverse disease.
A 2026 review of 32 human studies identifies which supplements genuinely support muscle, brain, metabolism, and immunity as we age.
A new review identifies protein, NAD⁺ precursors, antioxidants, and probiotics as top evidence-backed supplements for aging adults.
Restoring NAD+ levels in elderly patients' T cells reverses age-related dysfunction, offering a new 'Metabolic-Immunotherapy' approach for cancer treatment.
A landmark review reveals how declining NAD+ levels and disrupted circadian clocks form a vicious cycle driving dementia progression.
A comprehensive 2026 review reveals how mitochondrial self-cleaning gone wrong underlies neurodegeneration, heart disease, cancer, and aging.
AI4L uses 'Audit-Driven Prompting' to generate hallucination-free, evidence-based reviews of longevity therapies like senolytics and NAD+ boosters.
Expert reviews compare NMN and NR head-to-head. NMN edges out for muscle and sleep benefits; NR leads for neuroprotection.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
