83 articles
A new Nature Metabolism review reveals how mitochondrial maintenance systems govern healthy aging — and how NAD+, AMPK, and caloric restriction may restore them.
Aging adipose tissue loses its ability to generate new fat cells, driving insulin resistance. New review maps the molecular culprits and best treatment options.
New research reveals how mitochondrial NAD+ controls mitophagy to prevent cytosolic mtDNA from triggering chronic inflammation via the CGAS-STING pathway.
A C. elegans study finds V14™ outperforms AG1® in preserving movement with age, with transcriptomics revealing metabolic and stress-response pathway shifts.
New research links mitochondrial dysfunction in microglia to cellular senescence, revealing a key driver of brain aging.
Mike Lustgarten explores using cellular testing to screen longevity interventions personally before committing to them.
A new minimal model from physicists suggests aging is governed by just 3 variables — and most anti-aging drugs only address the first level.
Independent testing exposes widespread quality failures in NAD+ precursor supplements, with actionable guidance on which brands actually deliver.
A new review maps the molecular mechanisms behind liver aging and evaluates dietary, drug, and gene-editing interventions to slow decline.
A comprehensive review reveals how aging and disturbed blood flow reprogram endothelial cell metabolism, fueling atherosclerosis through glycolytic, lipid, and mitochondrial dysregulation.
A landmark review synthesizes 12 hallmarks of aging, emerging gerotherapeutics, and a new three-tier clinical care model to shift medicine from disease treatment to aging prevention.
A Danish case-control trial uses gold-standard metabolic testing to uncover how mtDNA mutations impair muscle glucose uptake and drive insulin resistance.
