How Gut Bacteria and Senescent Cells Team Up to Drive Age-Related Disease
A new review maps the bidirectional crosstalk between gut microbiota and cellular senescence driving multi-organ degeneration.
20 articles
A new review maps the bidirectional crosstalk between gut microbiota and cellular senescence driving multi-organ degeneration.
Age-related shifts in intestinal T cell populations may silently erode gut barrier function, accelerating the chronic inflammation that drives aging diseases.
Aging disrupts gut microbiota and mTOR signaling, crippling vaccine responses โ but targeted interventions may reverse this.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
A landmark review maps the structural, genetic, and molecular changes that erode lung function with age โ and why reversing them matters.
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
A landmark review maps the vaginal microbiome's role in infections and reproductive health, charting a path to precision probiotic therapies.
Scientists propose space environments as unique models for studying accelerated aging mechanisms and potential interventions.
A landmark review reveals how sustained glucocorticoid exposure drives aging biology โ and what can be done about it.
The British Society of Gastroenterology's expert panel takes stock of 10 years of microbiome advances and where the field is headed.
Specific mutational signatures accumulate linearly with age in normal tissues, offering a new window into why cancer risk rises exponentially as we get older.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
Bacteriophages transferred during FMT may drive horizontal gene transfer, altering microbial function and antibiotic resistance in ways science has largely ignored.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits โ reshaping diagnosis and treatment.
A landmark review reveals how diet, gut bacteria, and their metabolites determine the success of immune checkpoint blockade cancer therapy.
Fusobacterium nucleatum has shifted from suspected bystander to confirmed cancer driver โ here's what the science reveals.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.