Scientists Reprogram Brain Immune Cells to Clear Alzheimer's Plaques
A molecule called OLE restores microglia's protective function, reducing amyloid plaques and improving memory in animal models.
20 articles
A molecule called OLE restores microglia's protective function, reducing amyloid plaques and improving memory in animal models.
Cambridge researchers found a gene network that shuts off nerve repair — and an existing hormone drug that reactivates it.
New AI system reveals how genes control each other in Alzheimer's brains, uncovering potential treatment targets.
MIT researchers discovered that 30% of adult brain synapses are dormant but ready to activate, reshaping how we understand lifelong learning.
Blocking the protein PTP1B boosted memory and cleared brain plaque in mice, with potential links to diabetes and obesity treatment.
MIT researchers discovered how a schizophrenia gene mutation prevents brain adaptation to new information and found a way to restore normal function.
Scientists identify how cocaine rewires brain circuits through a protein that acts like a genetic switch, explaining addiction persistence.
A landmark study links epigenetic patterns at birth to infant gut microbiome development, with certain bacteria reducing neurodevelopmental risk by age three.
New gene therapy zorevunersen dramatically reduced seizures in children with severe Dravet syndrome epilepsy while improving quality of life.
Researchers turned ordinary brain cells into plaque-clearing machines, reducing Alzheimer's amyloid by half in mice with one treatment.
A new tool that boosts mitochondrial activity in neurons restored memory in dementia mice, suggesting energy failure drives Alzheimer's symptoms.
New NIH research reveals the brain-cell signaling mechanism behind GLP-1 drug plateaus and a potential way to extend their effects.
New technique maps thousands of neural connections simultaneously, potentially revolutionizing understanding of brain aging and disease.
Researchers restored a key brain circuit in mice and reversed anxiety and social withdrawal, pointing to a powerful new therapeutic target.
Researchers discover toxic protein pair that kills brain cells in Alzheimer's and develop compound to block it in mice.
UC San Diego study shows one week of intensive meditation produces measurable brain changes and enhanced neuroplasticity comparable to psychedelic effects.
New brain-targeted gene therapy mimics morphine's pain relief while avoiding addiction, offering hope for 50+ million Americans with chronic pain.
UC Davis scientists created novel brain-healing molecules that activate key serotonin receptors tied to neuroplasticity — without triggering hallucinations.
Buck Institute finds the longevity-linked APOE2 variant shields neurons from DNA damage and cellular senescence, explaining its Alzheimer's protection.
Scientists found acetylcholine surges after unexpected failure, triggering behavioral flexibility — with implications for addiction and OCD.