20 articles
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
Scientists discover adult brain cells keep epigenetic memories from development that may fuel gliomas but also enhance regeneration.
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.
Mendelian randomization study identifies 172 brain methylation sites that causally influence schizophrenia development.
DNA methylation biomarkers from a simple blood test may track cognitive aging and neurological disease risk with unprecedented precision.
Comprehensive review reveals how MECP2 mutations disrupt brain development and function in Rett syndrome, highlighting emerging therapeutic targets.
A newly identified GABAergic pathway in mice lets the brain toggle between updated and previous memories — a key insight for memory disorders.
A landmark review from UCL argues DBS goes beyond temporary neuromodulation to drive lasting structural brain changes.
New research reveals microglia actively silence and reshape fear-encoding neurons during extinction learning, opening new PTSD treatment avenues.
A single phosphorylation site on clock protein PER2, triggered by dietary fat, controls how fast mice synchronize to seasonal light cycles.
A chromatin-remodeling gene called SMARCAD1 controls tau levels — and switching it off could be a new therapeutic target for Alzheimer's.
New research maps how genes and environment interact to cause personality disorders, pointing to personalized drug treatments.
Scientists used stem cell-derived vesicles to deliver light-activated gene therapy to the brain without surgery, reversing cognitive decline in Alzheimer's mice.
A multinational study finds 56% of genetically diagnosed infants with epilepsy have variants potentially amenable to antisense oligonucleotide treatment.
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
A surprising new role for brain immune cells: microglia orchestrate glucose delivery to fuel memory-forming protein synthesis in active neurons.
New precision medicine approach combines genetic risk factors with environmental exposures to predict and prevent dementia.
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
Neuropixels recordings reveal how laminar microcircuits generate interictal epileptiform discharges — and how to predict them 1 second in advance.
