20 articles
Phosphatidylserine exposed on exhausted CD8 T cells suppresses immune responses — and blocking it boosts anti-tumor immunity.
Scientists uncover how phagocytic receptors cluster a key membrane lipid to activate LC3-associated phagocytosis, revealing a novel immune signaling mechanism.
Scientists find phosphatidylcholine loss fragments mitochondrial networks with age — and supplementing it may help reverse the damage.
Dive into the molecular architecture of age-related membrane deterioration — from phospholipase regulation and lipid raft proteomics to ferroptosis thresholds, ceramide signaling networks, and emerging lipid-targeted interventions.
Scientists find declining phosphatidylcholine disrupts mitochondria with age — and replenishing it quickly restores youthful cell energy.
A 1,030-person lipidomic study uncovers three distinct aging 'crests' and sex-divergent lipid shifts that reshape how we understand biological aging.
Scientists engineer high-PS procoagulant platelets that outperform thrombin and commercial hemostatic agents, even in antiplatelet-treated patients.
A 2025 review reveals how declining plasmalogen lipids signal disease severity across heart, brain, kidney, liver, and cancer conditions.
Silencing phospholipase PLAG-15 in C. elegans extends both lifespan and healthspan by modulating lysophospholipid levels and activating lysosomal genes.
A new partnership brings standardized spermidine into US clinical settings, shifting longevity science from shelves to physician-guided care.
A new study reveals how reduced ER-mitochondria contact in aging hearts disrupts lipid metabolism and blocks cellular recycling, accelerating cardiac decline.
A new class of retro-inverso peptides selectively destroys senescent brain cells via the FOXO4-p53 axis, restoring cognition in aged animal models.
SS-31 dramatically improves survival and brain recovery after cardiac arrest by blocking iron-driven cell death in microglia via the Sesn2 pathway.
New research reveals restoring tau protein balance, not just clearing tangles, could revolutionize Alzheimer's treatment.
Coptisine targets the STAT1/IRF1/GPX4 axis to halt ferroptosis in Kupffer cells, reducing sepsis-driven liver damage in mice and cell models.
ProJenX completes enrollment for Prosetin's Phase 1b ALS trial, reporting strong safety data and target engagement at therapeutic doses.
New research suggests certain dietary fats could trigger cell death in aging cells, potentially offering a natural senolytic approach.
MSC-derived exosomes significantly outperformed seminal plasma exosomes in protecting canine sperm motility, viability, and chromatin integrity during cryopreservation.
Fisetin encapsulated in liposomes significantly reduces IL-6 and IL-8 secretion in senescent lung cells, revealing potent senomorphic but not senolytic activity.
Scientists identify a glycolysis-serine axis controlled by PGK1 that governs podocyte aging, offering a new therapeutic target for chronic kidney disease.
