20 articles
Researchers discover a phospholipid derivative that protects brain cells by calming overactive immune cells in dementia-prone mice.
New research reveals how spermine promotes protein condensation and autophagy to combat neurodegeneration in lab models.
Cryo-EM reveals VPS13A and scramblase XK work together to ferry lipids across organelle contact sites, unlocking a fundamental cell biology mystery.
A boy with PLCB1-related epileptic encephalopathy showed improved seizure control and stabilized brain atrophy after high-dose enteral myo-inositol supplementation.
A 3-month fish hydrolysate supplement significantly improved episodic memory in healthy seniors showing accelerated cognitive decline, with reduced inflammation markers.
New research reveals how amyloid-ฮฒ triggers a calcium-cholesterol cascade in brain cells that clogs the glymphatic system โ and how statins may reverse it.
Review reveals how PQQ supplement protects neurons via antioxidant, mitochondrial, and anti-inflammatory mechanisms in neurodegenerative diseases.
Synthetic peptide chimeras degrade amyloid-beta across the blood-brain barrier, improving cognition in mice with fewer risks than current immunotherapies.
MIT researchers map how ABCA7 loss-of-function variants wreck phosphatidylcholine metabolism and mitochondria in neurons โ and find a potential fix.
A newly identified proteasome activator, PA200, clears toxic alpha-synuclein aggregates and maintains function even when standard protein-disposal systems fail.
A novel brain organoid stress model reveals how combining walnut peptide and theanine activates BDNF pathways to reduce anxiety and boost cognition.
A naturally occurring fatty acid amide activates immune cells in the retina, protecting neurons and blood vessels from degenerative damage.
Editorial raises concerns about influential 2009 study on Cerebrolysin's effects on brain degeneration in Alzheimer's models.
Scientists identify a rogue immune cell population fueling multiple sclerosis progression โ and a promising drug target to stop it.
Cerebral hypoperfusion drives glymphatic dysfunction in systemic inflammation โ and restoring blood flow with levosimendan reverses it.
Deleting or inhibiting astrocytic PERK restores the brain's glymphatic drainage system and dramatically reduces Aฮฒ and tau pathology in AD mouse models.
Study shows 2'-fucosyllactose improves cognitive function in mice by modulating gut microbiota and brain serotonin levels.
Combining psilocybin with D-serine or D-cycloserine dramatically reduced hallucinogenic effects while enhancing neuroplasticity markers in mice.
PEMFs repair mitochondrial damage and boost brain signaling pathways in stressed neurons, offering new therapeutic hope.
A traditional Chinese herbal formula improves cognition and cerebrovascular health in Alzheimer's mice by activating the LKB1-AMPK-SIRT1 autophagy cascade.
