20 articles
New research shows phosphatidylserine supplementation reduces liver fat and inflammation while improving glucose control through enhanced fat metabolism.
Phosphatidylserine exposed on exhausted CD8 T cells suppresses immune responses โ and blocking it boosts anti-tumor immunity.
Scientists uncover how phagocytic receptors cluster a key membrane lipid to activate LC3-associated phagocytosis, revealing a novel immune signaling mechanism.
Researchers discover a phospholipid derivative that protects brain cells by calming overactive immune cells in dementia-prone mice.
New research reveals how spermine promotes protein condensation and autophagy to combat neurodegeneration in lab models.
A 1,030-person lipidomic study uncovers three distinct aging 'crests' and sex-divergent lipid shifts that reshape how we understand biological aging.
A 2025 review reveals how declining plasmalogen lipids signal disease severity across heart, brain, kidney, liver, and cancer conditions.
Cryo-EM reveals VPS13A and scramblase XK work together to ferry lipids across organelle contact sites, unlocking a fundamental cell biology mystery.
A boy with PLCB1-related epileptic encephalopathy showed improved seizure control and stabilized brain atrophy after high-dose enteral myo-inositol supplementation.
Silencing phospholipase PLAG-15 in C. elegans extends both lifespan and healthspan by modulating lysophospholipid levels and activating lysosomal genes.
A new study reveals how reduced ER-mitochondria contact in aging hearts disrupts lipid metabolism and blocks cellular recycling, accelerating cardiac decline.
A new class of retro-inverso peptides selectively destroys senescent brain cells via the FOXO4-p53 axis, restoring cognition in aged animal models.
SS-31 dramatically improves survival and brain recovery after cardiac arrest by blocking iron-driven cell death in microglia via the Sesn2 pathway.
New research reveals restoring tau protein balance, not just clearing tangles, could revolutionize Alzheimer's treatment.
50 nm polystyrene nanoplastics accumulate in mouse testes, degrading sperm quality and triggering iron-dependent cell death through a newly identified mitochondrial pathway.
New research suggests certain dietary fats could trigger cell death in aging cells, potentially offering a natural senolytic approach.
A 3-month fish hydrolysate supplement significantly improved episodic memory in healthy seniors showing accelerated cognitive decline, with reduced inflammation markers.
New research reveals how amyloid-ฮฒ triggers a calcium-cholesterol cascade in brain cells that clogs the glymphatic system โ and how statins may reverse it.
A landmark Nature study reveals PCSK9 levels in pancreatic cancer cells dictate whether tumors metastasize to the liver or lungs via cholesterol metabolism.
A PAT-derived lipid, LPE18:1, hijacks a CAPZA1/USP48/SIRT6 axis to reprogram cholesterol metabolism and drive clear cell renal cell carcinoma.
