20 articles
A validated UPLC-MS/MS method analyzing 566 plasma samples reveals key patient factors that explain why standard antidepressant doses fail many people.
After ischemic stroke, a mislocated brain water channel (AQP4) disrupts waste clearance. Blocking AQP4 with TGN-020 corrects its position and restores glymphatic flow.
A Phase 2 trial investigates whether thiethylperazine, a decades-old antiemetic, can flush toxic amyloid beta from the brains of early AD patients.
A Japanese RCT shows tenecteplase (0.25 mg/kg) achieves 3x higher early recanalization than low-dose alteplase (0.6 mg/kg) in LVO stroke patients.
Contraloid acetate, an oral all-D-peptide designed to disassemble toxic amyloid-beta oligomers, completed its first-in-human safety trial in 40 healthy volunteers.
A post hoc analysis of the DISTAL trial finds EVT plus medical therapy significantly improves brain tissue preservation in hard-to-reach vessel occlusions.
Cerebral hypoperfusion drives glymphatic dysfunction in systemic inflammation โ and restoring blood flow with levosimendan reverses it.
A Harvard-developed digital seed amplification assay can precisely quantify TDP-43 protein aggregates in CSF, offering a potential diagnostic breakthrough for frontotemporal dementia.
A Mayo Clinic study reveals the Lumipulse p-tau217/Aฮฒ42 plasma ratio has variable accuracy in detecting Alzheimer's amyloid pathology.
A Phase 1/2 trial tests whether dexmedetomidine can enhance the brain's glymphatic system to clear amyloid and tau during sleep.
A first-in-human multiple-ascending-dose trial tests Contraloid, an oral peptide designed to disassemble toxic amyloid-beta oligomers linked to Alzheimer's disease.
Inhibiting TRPV4 channels in mice restored glymphatic drainage, cut cerebral edema, and improved neurological recovery after ischemic stroke.
Italian researchers developed a biosensor to track extracellular vesicles in blood, potentially personalizing stroke rehabilitation.
New study shows plasma pTau217 test reliably identifies Alzheimer's pathology in the brain, even when other dementia types are present.
New research questions the continued use of IV alteplase for stroke treatment, potentially reshaping emergency care protocols.
DPCPX treatment enhanced neurogenesis and improved motor/memory function in stroke recovery studies using advanced PET imaging.
Advanced brain imaging in stroke patients challenges assumptions about how the brain clears waste through its drainage pathways.
Bilateral theta burst stimulation enhanced neural repair and restored function after stroke in non-human primates through multiple mechanisms.
Plasma p-tau217 accurately detects preclinical Alzheimer's in cognitively normal adults, potentially enabling earlier intervention.
Scientists used red blood cells to transport healthy mitochondria into diseased brain cells, showing promise for Parkinson's treatment.
