20 articles
A validated UPLC-MS/MS method analyzing 566 plasma samples reveals key patient factors that explain why standard antidepressant doses fail many people.
After ischemic stroke, a mislocated brain water channel (AQP4) disrupts waste clearance. Blocking AQP4 with TGN-020 corrects its position and restores glymphatic flow.
A Japanese RCT shows tenecteplase (0.25 mg/kg) achieves 3x higher early recanalization than low-dose alteplase (0.6 mg/kg) in LVO stroke patients.
A post hoc analysis of the DISTAL trial finds EVT plus medical therapy significantly improves brain tissue preservation in hard-to-reach vessel occlusions.
Cerebral hypoperfusion drives glymphatic dysfunction in systemic inflammation โ and restoring blood flow with levosimendan reverses it.
A Harvard-developed digital seed amplification assay can precisely quantify TDP-43 protein aggregates in CSF, offering a potential diagnostic breakthrough for frontotemporal dementia.
A Mayo Clinic study reveals the Lumipulse p-tau217/Aฮฒ42 plasma ratio has variable accuracy in detecting Alzheimer's amyloid pathology.
Inhibiting TRPV4 channels in mice restored glymphatic drainage, cut cerebral edema, and improved neurological recovery after ischemic stroke.
New study shows plasma pTau217 test reliably identifies Alzheimer's pathology in the brain, even when other dementia types are present.
New research questions the continued use of IV alteplase for stroke treatment, potentially reshaping emergency care protocols.
DPCPX treatment enhanced neurogenesis and improved motor/memory function in stroke recovery studies using advanced PET imaging.
Advanced brain imaging in stroke patients challenges assumptions about how the brain clears waste through its drainage pathways.
Bilateral theta burst stimulation enhanced neural repair and restored function after stroke in non-human primates through multiple mechanisms.
Plasma p-tau217 accurately detects preclinical Alzheimer's in cognitively normal adults, potentially enabling earlier intervention.
New research examines why blood pressure falls after stroke procedures and what it means for patient outcomes.
Combining psilocybin with D-serine or D-cycloserine dramatically reduced hallucinogenic effects while enhancing neuroplasticity markers in mice.
New research reveals that blood pressure drops within 24 hours after stroke treatment significantly impair functional recovery.
A global consortium reveals how tube type, delays, and storage temperature dramatically skew key Alzheimer's blood biomarker readings.
Synthetic peptide chimeras degrade amyloid-beta across the blood-brain barrier, improving cognition in mice with fewer risks than current immunotherapies.
Researchers identify transthyretin (TTR) as a potential biomarker for postoperative cognitive dysfunction, offering new diagnostic hope.
