Why Alzheimer's and Parkinson's Share a Protein Misfolding Network
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits โ reshaping diagnosis and treatment.
20 articles
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits โ reshaping diagnosis and treatment.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
A landmark 48-RCT Cochrane review finds high-certainty evidence that convalescent plasma does not reduce death in moderate-to-severe COVID-19.
A Dana-Farber review maps the path for personalized cancer vaccines โ pinpointing which tumors, timing, and combination strategies will matter most.
New computational advances help identify which tumor peptides trigger immune responses, potentially revolutionizing personalized cancer therapy.
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
A Cochrane meta-analysis of 17 RCTs finds blue light TURBT reduces bladder cancer recurrence and progression, especially in intermediate- and high-risk patients.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
A landmark AHA scientific statement tackles inconsistent cardiovascular safety reporting in oncology trials with a unified framework.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.
A major Lancet review reveals 27 million women suffer postpartum haemorrhage annually, costing $10.4B and claiming 43,000 lives โ with most deaths preventable.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
A new review links adult cholestasis to pediatric genetic syndromes, opening doors to targeted therapies including novel bile acid transport inhibitors.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
Expert reviews rank fisetin and quercetin as top senolytics, with spermidine and resveratrol as supporting players in longevity supplement stacks.
A Cochrane review of 4 RCTs finds no reliable evidence that adding endovascular stenting to medical therapy prevents stroke or death in vertebral artery stenosis.
A translational review outlines how stem cell technologies may finally make hepatocyte-based liver therapies clinically viable.
A Cochrane meta-analysis of 11 RCTs finds very low-certainty evidence that liver support systems neither reduce mortality nor improve key outcomes in ALF.
New review reveals how advanced genomics tools are revolutionizing cancer diagnosis and therapy development.
Expert reviews confirm NR and NMN raise blood NAD+, but longevity proof remains elusive and product quality varies widely.