20 articles
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
DNA methylation biomarkers from a simple blood test may track cognitive aging and neurological disease risk with unprecedented precision.
IRISeq maps gene expression across aging mouse brains, finding lymphocytes fuel neuroinflammation and accelerate cellular aging.
Boosting BNIP3 in muscle tissue extends fly lifespan and shields the brain from age-related degeneration via a muscle-brain signaling axis.
Study of 833 people finds depression linked to premature biological aging in both brain structure and DNA methylation patterns.
Comprehensive review of 2021-2025 proteomics reveals 866 consensus protein changes and novel therapeutic targets in Alzheimer's disease.
A multi-omics analysis of over 1 million brain cells reveals how neurotransmitter systems change across aging and eight neuropsychiatric disorders.
27-Hydroxycholesterol triggers microglial senescence through iron dysregulation, and the iron chelator deferoxamine reverses the damage.
New research identifies specific blood markers that independently predict both physical frailty and cognitive decline.
New Nature Medicine research links harmful physical and social exposures to accelerated brain aging, with major implications for dementia prevention.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
New mouse study reveals aging causes region-specific neuroinflammation and perineuronal net accumulation linked to memory decline.
Scientists uncover the molecular mechanisms driving microglial aging in the brain, offering insights into neurodegeneration.
A landmark multicohort proteomics study reveals how APOE2 and APOE4 shape Alzheimer's risk through entirely distinct molecular mechanisms.
A 4-protein panel in neuronal extracellular vesicles outperforms standard plasma tests in flagging early Alzheimer's brain changes.
New molecular mapping technique identifies individuals uniquely and predicts cognitive decline more accurately than standard brain scans.
New review reveals how senescent brain cells fuel Alzheimer's progression and highlights promising senolytic therapies for cognitive protection.
New research reveals that inconsistent sleep timing and quality drive faster accumulation of toxic brain proteins linked to Alzheimer's disease.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
New research reveals how context-dependent protein interactions regulate TDP-43 dysfunction in ALS and frontotemporal dementia.
