20 articles
Senescent cells drive cyst growth in ADPKD, and targeting them with senolytics or the aldose reductase inhibitor epalrestat delays disease progression.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
Natural flavonoid fisetin activates mitophagy and xenophagy pathways to restrict intracellular Salmonella growth in immune cells.
A deep mechanistic exploration of neutrophil extracellular trap biology in the context of aging — from PAD4 citrullination dynamics and gasdermin-driven release to clinical immunopathology and next-generation therapeutic targets.
Demethyleneberberine, derived from traditional Chinese medicine, significantly reduced lung scarring by targeting NLRP3 inflammasome and EMT in mice.
New research identifies Lp-PLA2 enzyme as therapeutic target for deadly lung disease affecting millions of workers worldwide.
Dying cancer cells release GPX4 protein that prevents immune system activation, revealing new immunotherapy targets.
A completed trial tests whether diode laser treatment reduces TLR-4 in saliva, linking periodontal inflammation to systemic aging biology.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
Master the molecular architecture of complement dysregulation in aging — from regulatory protein biochemistry to cutting-edge therapeutic targets — and understand how precision interventions can restore balance without dismantling immunity.
New research reveals how SIRT2 regulates T cell responses, potentially improving cancer immunotherapy and immune function.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
Scientists discover how blocking CD40-CD40L pathway reduces dangerous clotting in antiphospholipid syndrome patients.
Pyruvate, a core metabolic molecule, suppresses interferon signaling by directly modifying STAT1 — linking metabolism to immune control.
Go deeper into the molecular machinery of neutrophil extracellular traps — how they form, what activates them with age, and why clearing them becomes increasingly difficult over time.
Discover how your immune cells set microscopic traps to fight infections — and why those same traps can silently fuel inflammation and speed up aging.
Stanford researchers used modified immune proteins to enhance neurogenesis and cognitive function in aged mouse brains.
New research reveals how immune cells use cysteine for both antioxidant defense and energy production, with major implications for cancer treatment.
Go beyond inflammaging basics to understand how aging reshapes immune cell populations, triggers the SASP, and locks the body into a state of chronic low-grade inflammation at the molecular level.
A phase 1/2 trial finds low-dose oral NMN safely raises platelet counts in steroid-refractory ITP via a novel immunometabolic mechanism.
