Cancer Research
Senolytics Fail to Protect Bone From Chemotherapy-Induced Loss
A mouse study finds that senolytic drugs cannot prevent chemotherapy-driven bone loss, challenging a leading hypothesis about its cause.
Research Paper
May 7, 2026 0
Results for "Quercetin Senolytic" in Cancer
20 articles
Cancer Research
New Prodrug and Nano Delivery Systems Target Senescent Cancer Cells
Scientists develop advanced drug delivery methods to detect and eliminate harmful senescent tumor cells that promote cancer spread.
Research Paper
Apr 9, 2026 0
Cancer Research
NK Cell Vesicles Deliver One-Two Punch Against Osteosarcoma Using Senolytics
Engineered immune cell vesicles first induce cancer cell senescence with chemo, then eliminate them with targeted senolytic drugs.
Research Paper
Apr 3, 2026 0
Cancer Research
Senescent B Cells Drive Cancer Immunotherapy Resistance in Esophageal Cancer
Study identifies senescent EGR1+ B cells that sabotage immunotherapy in esophageal cancer, with fisetin showing promise as a therapeutic enhancer.
Research Paper
Apr 2, 2026 0
Cancer Research
Hidden Protein Shields Liver Cancer Cells From a Key Cell Death Pathway
Scientists uncover how SCRN1 blocks ferroptosis in liver cancer, revealing new targets for treating drug-resistant hepatocellular carcinoma.
Research Paper
May 22, 2026 0
Cancer Research
Senescent Tumor Cells Expressing PD-L2 Blunt Chemotherapy Effectiveness
Intratumoral senescent cells shielded by PD-L2 may explain why chemotherapy often falls short — and point to a new combination strategy.
Research Paper
Jun 3, 2026 0
Cancer Research
Urine Test May Soon Track Senescent Cells in Cancer and Fibrosis
Cambridge scientists engineer a nanoprobe that detects therapy-induced senescence non-invasively through a simple urine colorimetric test.
Research Paper
May 14, 2026 0
Cancer Research
Lysosomal Disruption Boosts Cancer Drug Effectiveness Against RNA Polymerase
Researchers discover how cancer cells use lysosomes to resist RNA polymerase inhibitors and develop combination strategies to overcome this resistance.
Research Paper
Apr 2, 2026 0
Cancer Research
PROTAC Nanomedicine Destroys Cancer Protein to Trigger Cell Death via Ferroptosis
Novel nanoparticle combines protein degrader with light therapy to reprogram cancer metabolism and eliminate breast tumors.
Research Paper
Apr 4, 2026 0
Cancer Research
Common Supplement PQQ Found to Block Cancer-Driving Enzyme in Lymphoma Cells
PQQ, a widely available dietary supplement, inhibits EZH2 and suppresses B-cell lymphoma proliferation in lab studies.
Research Paper
Apr 23, 2026 0
Cancer Research
PQQ Shows Anticancer Promise But Needs Clinical Trials to Prove It
Pyrroloquinoline quinone has demonstrated anticancer activity in preclinical studies, but human cancer trials remain absent. Here's where the science stands.
Research Paper
Apr 24, 2026 0
Cancer Research
Mitochondria-Targeted Nanozyme Triggers Dual Cancer Cell Death Pathways
Novel nanoplatform delivers copper and iron ions to trigger both ferroptosis and cuproptosis in cancer cells.
Research Paper
Apr 7, 2026 0
Cancer Research
RNA Polymerase Inhibitor CX-5461 Triggers Cancer Cell Death via Iron Overload
New study reveals how blocking ribosome production makes cancer cells vulnerable to ferroptosis, an iron-dependent cell death pathway.
Research Paper
Apr 4, 2026 0
Cancer Research
Ferroptosis Boosts Anti-Tumor Immunity by Degrading the Immune Suppressor SHP2
RSL3-induced ferroptosis degrades SHP2 via chaperone-mediated autophagy, amplifying IFN-γ/STAT1 signaling and enhancing anti-PD-1 immunotherapy efficacy.
Research Paper
May 22, 2026 0
Cancer Research
Chemotherapy Awakens Dormant Cancer Cells Through Neutrophil Traps
Study reveals how common cancer drugs trigger dormant tumor cells to reactivate and spread, offering new prevention strategies.
Research Paper
Mar 29, 2026 1
Cancer Research
New Macrocyclic Peptides Selectively Kill Chemotherapy-Resistant Lung Cancer Cells
Orally bioavailable cyclin A/B RxL inhibitors exploit a cell-cycle vulnerability in small-cell lung cancer and other G1-S-checkpoint-deficient tumors.
Research Paper
May 18, 2026 0
Cancer Research
Ginseng Compound Rh4 Fights Colorectal Cancer by Reshaping Gut Bacteria and Bile Acids
Ginsenoside Rh4 suppresses colorectal cancer by boosting Akkermansia muciniphila and elevating protective bile acid UDCA via FXR signaling.
Research Paper
Jun 1, 2026 0
Cancer Research
Antidepressants Sertraline and Indatraline Trigger Cancer Cell Death via Cholesterol
Two common antidepressants cause cholesterol buildup in cancer cell lysosomes, triggering immunogenic cell death that helps immune system fight tumors.
Research Paper
Apr 5, 2026 0
Cancer Research
New Strategy Boosts Cancer Drug Effectiveness by Preventing Protein Breakdown
Researchers found that stopping HER2 protein degradation significantly improves trastuzumab deruxtecan cancer treatment outcomes.
Research Paper
Mar 29, 2026 3
Cancer Research
Exosomes from senescent cells could revolutionize cancer therapy delivery
New research reveals how tiny cellular packages from aging cells might be engineered to deliver targeted cancer treatments.
Research Paper
Apr 9, 2026 0
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