20 articles
A 2026 review evaluates how two common dietary flavonoids target senescent cells, potentially slowing aging and age-related disease.
A 2025 review maps how quercetin fights senescence, oxidative stress, and inflammation in AMD, cataract, diabetic retinopathy, and glaucoma.
A sweeping 2025 review maps how the plant compound quercetin combats cardiovascular disease, dementia, osteoporosis, and more at the molecular level.
Study shows senolytic combination therapy reduces cellular aging in gums and prevents periodontal bone loss in aging mice.
Eight months of dasatinib plus quercetin treatment restored blood vessel function in aged mice by eliminating senescent endothelial cells.
Clinical trial tests whether senolytic compounds can reduce cellular aging burden and improve bone health markers in older adults.
A landmark single-cell study maps how dasatinib + quercetin reshapes aging across multiple tissues, revealing timing matters as much as the drug itself.
Dasatinib plus quercetin cleared senescent cells and reduced inflammation, improving alveolar bone health in aged mice.
A randomized trial finds quercetin reduces vascular senescence and inflammation in male CAD patients undergoing bypass surgery, with no benefit in females.
A phase 1 trial of dasatinib + quercetin in 5 early AD patients uncovers fluid biomarker changes that could guide future senolytic trials.
D+Q senolytics reshaped gut microbiota and serum metabolites to reverse diabetic osteoporosis in mice, pointing toward a novel therapeutic avenue.
Dasatinib and quercetin clear senescent cochlear cells, reducing inflammation and preserving hair cells in aging mice.
New research reveals how drugs that eliminate senescent cells could complement existing Alzheimer's treatments by reducing brain inflammation.
A medicinal-chemistry optimized flavonol called F-4N shows 50× greater senolytic potency than quercetin and resolves lung fibrosis in animal models.
Clinical trial tests whether dasatinib plus quercetin can reduce liver scarring in fatty liver disease patients.
A natural flavonoid delivered via injectable hydrogel suppresses senescence pathways in tendon stem cells, dramatically improving aged tendon healing.
Four anti-aging compounds — quercetin, fisetin, dasatinib, and sirolimus — all shifted gut microbiome composition toward healthier aging profiles.
Natural compounds like quercetin eliminate harmful senescent cells in the uterus, improving decidualization and reducing migration linked to endometriosis.
4-month senolytic treatment with D+Q cleared senescent RPE cells, reduced lipofuscin, and preserved vision in a preclinical dry AMD model.
Meta-analysis of 65 studies reveals quercetin's powerful effects on skin aging, wound healing, and protection against oxidative damage.
