68 articles
New research reveals antioxidants can selectively eliminate senescent muscle cells by correcting faulty mTOR nutrient-sensing pathways linked to aging.
Leading scientists gathered at the 12th progeria workshop to assess breakthrough therapies for this ultra-rare accelerated aging disease.
Go beneath the surface of senescent cell biology to understand the precise molecular machinery driving the SASP — and how these signals corrupt neighboring cells, fuel inflammation, and accelerate tissue aging.
A 2025 review maps the full biology of hair graying—from oxidative stress to stem cell loss—and evaluates emerging prevention and treatment options.
A massive multi-species transcriptomic study reveals conserved molecular hallmarks of aging and mortality, uncovering modular architecture linking inflammation, mitochondria, and chromatin.
In LAM lung disease, mTOR-hyperactive cells secrete IL-6 that pushes neighboring stem cells into senescence, blocking lung repair—and Tocilizumab may help.
A comprehensive review reveals how the senescence secretome suppresses tumors early but drives progression, resistance, and metastasis chronically.
Worn-out monocytes transmit their dysfunctional state to healthy neighbors via direct contact, with CD38 and mTOR as central drivers.
Montara Therapeutics wins MJFF funding to activate brain autophagy using mTOR inhibitors — without dangerous whole-body side effects.
Researchers repurpose mRNA-lipid nanoparticle technology to prevent and treat allergic asthma in mice, achieving ~100-fold reduction in airway eosinophils.
Calcium alpha-ketoglutarate rescues memory-related synaptic plasticity in Alzheimer's mice, pointing to a geroprotective supplement as a potential AD therapy.
A comprehensive 2025 review maps the molecular drivers of cardiac aging and evaluates interventions from rapamycin to gene editing.
