Brain Health
GLP-1 and PPARγ Drugs Show Direct Brain Insulin-Signaling Effects
Stanford researchers find pioglitazone and liraglutide improve CNS insulin signaling, measured via neuron-derived vesicles in blood.
Research Paper
Apr 20, 2026 0
Results for "SGLT2 Inhibitors" in Parkinson's
20 articles
Brain Health
Oral GLP-1 Drug Crosses Blood-Brain Barrier to Reverse Alzheimer's Metabolism
A new oral GLP-1 receptor agonist penetrates the brain, restoring astrocyte-neuron metabolic crosstalk disrupted in Alzheimer's disease.
Research Paper
Jun 23, 2026 0
Brain Health
Breast Milk Sugar 2'-FL Boosts Memory and Learning Through Gut Bacteria
Study shows 2'-fucosyllactose improves cognitive function in mice by modulating gut microbiota and brain serotonin levels.
Research Paper
Apr 2, 2026 0
Brain Health
Diabetes Treatment May Mask Alzheimer's Biomarker Signals in Research
A new study warns that diabetes medications could confound Alzheimer's biomarker studies, distorting our understanding of the diabetes-dementia link.
Research Paper
May 13, 2026 0
Brain Health
Melatonin Blocks Toxic Protein Clumps That Drive Diabetes and Alzheimer's Disease
New research reveals how melatonin prevents harmful protein aggregation linked to both type 2 diabetes and brain degeneration.
Research Paper
Mar 28, 2026 1
Brain Health
New ALS Drug Tofersen Shows Promise in Long-Term Study for SOD1 Patients
Breakthrough antisense therapy demonstrates sustained benefits for rare genetic form of ALS in extended clinical trial.
Research Paper
Mar 29, 2026 1
Brain Health
Brain Glucose Levels Control Myelin Cell Growth Through Epigenetic Switching
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.
Research Paper
May 3, 2026 0
Brain Health
TSC2 Gene Loss Disrupts Brain Development by Blocking Key Protein Production
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
Research Paper
Mar 29, 2026 2
Brain Health
Myo-Inositol Supplementation Reduces Seizures in Rare Childhood Epileptic Encephalopathy
A boy with PLCB1-related epileptic encephalopathy showed improved seizure control and stabilized brain atrophy after high-dose enteral myo-inositol supplementation.
Research Paper
Jun 23, 2026 0
Brain Health
ALS Protein Disrupts Brain Energy Production by Hijacking Key Metabolic Enzyme
New research reveals how TDP-43 protein causes energy failure in motor neurons, pointing to potential metabolic therapies for ALS.
Research Paper
Mar 28, 2026 2
Brain Health
Single Gene Injection Shields Retinal Cells From Glaucoma Damage
AAV delivery of AIBP protein restores cholesterol balance, silences inflammation, and preserves vision in glaucoma models.
Research Paper
Jun 22, 2026 0
Brain Health
Intranasal Insulin Reverses Memory Loss and Brain Inflammation in Aging Mouse Model
A 9-day intranasal insulin regimen restored working memory, recognition memory, and reduced neuroinflammation in mice engineered to mimic hippocampal aging.
Research Paper
Apr 30, 2026 0
Brain Health
Small Molecule XL20 Extends ALS Mouse Survival by Targeting TDP-43 Toxicity
A brain-penetrant compound targets a key region of TDP-43, reducing motor neuron loss and extending survival in ALS mouse models.
Research Paper
Jul 4, 2026 0
Brain Health
Metabolic Therapy Prevents Childhood Stroke Disease in Genetic Mouse Model
Nicotinamide riboside prevents moyamoya-like brain vessel blockages by fixing cellular energy production in smooth muscle cells.
Research Paper
Apr 4, 2026 0
Brain Health
mTOR Mutations Drive Smith-Kingsmore Syndrome and Hint at Rapamycin Therapy
A GeneReviews update details how activating MTOR variants cause a rare overgrowth-intellectual disability syndrome, with early rapamycin trials showing promise.
Research Paper
Apr 19, 2026 0
Brain Health
Combination Neuroprotective Compounds Show Promise for Glaucoma Vision Loss
New review reveals how combining citicoline, CoQ10, and other agents may protect retinal cells better than single treatments.
Research Paper
Apr 4, 2026 0
Brain Health
Boosting Brain Blood Flow Rescues the Brain's Waste-Clearance System During Sepsis
Cerebral hypoperfusion drives glymphatic dysfunction in systemic inflammation — and restoring blood flow with levosimendan reverses it.
Research Paper
May 14, 2026 0
Brain Health
Novel Brain Compound Shows Promise Against Alzheimer's in Mice Studies
SOMCL-668 improved memory and reduced brain damage in Alzheimer's mice by targeting sigma-1 receptors and protective pathways.
Research Paper
Mar 29, 2026 1
Brain Health
Herbal Compound Clears Alzheimer's Plaques by Activating AMPK Autophagy Pathway
A traditional Chinese herbal formula improves cognition and cerebrovascular health in Alzheimer's mice by activating the LKB1-AMPK-SIRT1 autophagy cascade.
Research Paper
May 21, 2026 0
Brain Health
New Antidepressant Strategy Targets Brain Receptors for Rapid Relief
Scientists develop pathway-selective drug that activates beneficial brain receptors while avoiding negative feedback loops.
Research Paper
Apr 8, 2026 0
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